Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 8/20 | 0.43 |
| ▸ | NAMPT | P43490 | 3/20 | 0.43 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.38 |
| ▸ | MEN1 | O00255 | 5/20 | 0.38 |
| ▸ | GAA | P10253 | 4/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | SENP1 | Q9P0U3 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.36 |
| ▸ | ABL1 | P00519 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2572833 | 0.93 | HIF1A (0.38) | MAPTNAMPTKMT2AGAANPC1 | |
| SCHEMBL3147765 | 0.91 | LTA4H (0.36) | MAPTNAMPTKMT2AMEN1NPC1 | |
| SCHEMBL3160809 | 0.91 | OPRM1 (0.36) | MAPTNAMPT | |
| SCHEMBL480833 | 0.90 | MAPT (0.44) | MAPTNAMPTRXFP1SMN1; SMN2KMT2A | |
| SCHEMBL2569221 | 0.89 | RXFP1 (0.44) | MAPTNAMPTRXFP1SMN1; SMN2KMT2A | |
| SCHEMBL479462 | 0.89 | MAPT (0.43) | MAPTNAMPTRXFP1SMN1; SMN2KMT2A | |
| SCHEMBL479583 | 0.89 | MAPT (0.48) | MAPTNAMPTRXFP1SMN1; SMN2KMT2A | |
| SCHEMBL479587 | 0.89 | MAPT (0.48) | MAPTNAMPTRXFP1SMN1; SMN2KMT2A | |
| SCHEMBL479585 | 0.89 | MAPT (0.48) | MAPTNAMPTRXFP1SMN1; SMN2KMT2A | |
| SCHEMBL4493463 | 0.88 | FPR2 (0.34) | MAPTSMN1; SMN2KMT2AMEN1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2157081-A1 | Indolinones substituted in six locations, their manufacture and their application as medicine | Boehringer Ingelheim Pharma GmbH & Co. KG (DE) | 2010-02-24 | — | — | EP | disclosed |
| US-6762180-B1 | Substituted indolines which inhibit receptor tyrosine kinases | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2004-07-13 | — | — | US | disclosed |