Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM6B | O15054 | 2/20 | 0.63 |
| ▸ | KDM4A | O75164 | 2/20 | 0.63 |
| ▸ | KDM4D | Q6B0I6 | 2/20 | 0.63 |
| ▸ | HIF1AN | Q9NWT6 | 2/20 | 0.63 |
| ▸ | KDM2A | Q9Y2K7 | 2/20 | 0.63 |
| ▸ | CA12 | O43570 | 4/20 | 0.56 |
| ▸ | CA1 | P00915 | 4/20 | 0.56 |
| ▸ | CA2 | P00918 | 4/20 | 0.56 |
| ▸ | CA6 | P23280 | 4/20 | 0.56 |
| ▸ | CA7 | P43166 | 4/20 | 0.56 |
| ▸ | CA13 | Q8N1Q1 | 4/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.53 |
| ▸ | MAPT | P10636 | 3/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.53 |
| ▸ | GAA | P10253 | 3/20 | 0.53 |
| ▸ | POLB | P06746 | 2/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.53 |
| ▸ | KDM3B | Q7LBC6 | 1/20 | 0.53 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15349519 | 0.97 | KDM6B (0.60) | KDM6BKDM4AKDM4DHIF1ANKDM2A | |
| SCHEMBL10766398 | 0.87 | KDM4E (0.55) | KDM6BKDM4AKDM4DHIF1ANKDM2A | |
| SCHEMBL11013238 | 0.83 | CA12 (0.57) | KDM6BKDM4AKDM4DHIF1ANKDM2A | |
| SCHEMBL10783573 | 0.83 | KDM6B (0.57) | KDM6BKDM4AKDM4DHIF1ANKDM2A | |
| SCHEMBL1014580 | 0.81 | KDM4E (0.58) | CA12CA1CA2CA6CA7 | |
| SCHEMBL12408070 | 0.80 | KDM6B (0.44) | KDM6BKDM4AKDM4DHIF1ANKDM2A | |
| SCHEMBL2217764 | 0.79 | KDM4E (0.53) | CA12CA1CA2CA6CA7 | |
| SCHEMBL7997265 | 0.79 | KDM4E (0.55) | CA12CA1CA2CA6CA7 | |
| SCHEMBL2902593 | 0.79 | ALDH1A1 (0.66) | CA12CA1CA2CA6CA7 | |
| SCHEMBL18585976 | 0.79 | ALDH1A1 (0.59) | CA12CA1CA2CA6CA7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 35 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0225175-A2 | Dihydropyridine derivatives, processes for their preparation and pharmaceutical compositions thereof | FISONS plc (GB) | 1987-06-10 | — | — | EP | claimed |
| JP-60100559-A | — | — | None | — | — | JP | disclosed |
| US-10364247-B2 | Preparation and use of novel protein kinase inhibitors | RUIJIN HOSPITAL AFFILIATED TO SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE (CN) | 2019-07-30 | — | — | US | disclosed |
| EP-2841070-B1 | DESIGN AND SYNTHESIS OF NOVEL INHIBITORS OF ISOPRENOID BIOSYNTHESIS | UNIV NORTHERN ILLINOIS BOARD OF TRUSTEES (US) | 2018-07-25 | — | — | EP | disclosed |
| US-20180105528-A1 | PREPARATION AND USE OF NOVEL PROTEIN KINASE INHIBITORS | BRANDEIS UNIVERSITY | 2018-04-19 | — | — | US | disclosed |
| US-20180105528-A1 | PREPARATION AND USE OF NOVEL PROTEIN KINASE INHIBITORS | BRANDEIS UNIVERSITY | 2018-04-19 | — | — | US | disclosed |
| US-9890126-B2 | Synthesis of novel inhibitors of isoprenoid biosynthesis (ISPF) | BOARD OF TRUSTEES OF NORTHERN ILLINOIS UNIVERSITY (US) | 2018-02-13 | — | — | US | disclosed |
| US-9890126-B2 | Synthesis of novel inhibitors of isoprenoid biosynthesis (ISPF) | BOARD OF TRUSTEES OF NORTHERN ILLINOIS UNIVERSITY (US) | 2018-02-13 | — | — | US | disclosed |
| US-9890126-B2 | Synthesis of novel inhibitors of isoprenoid biosynthesis (ISPF) | BOARD OF TRUSTEES OF NORTHERN ILLINOIS UNIVERSITY (US) | 2018-02-13 | — | — | US | disclosed |
| WO-2016168992-A1 | PREPARATION AND USE OF NOVEL PROTEIN KINASE INHIBITORS | RUIJIN HOSPITAL AFFILIATED TO SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE (CN) | 2016-10-27 | — | — | WO | disclosed |
| WO-2013163159-A2 | DESIGN AND SYNTHESIS OF NOVEL INHIBITORS OF ISOPRENOID BIOSYNTHESIS | BOARD OF TRUSTEES OF NORTHERN ILLINOIS UNIVERSITY (US) | 2013-10-31 | — | — | WO | disclosed |
| US-20100010025-A1 | Pyrimidine Derivatives | NORVARTIS AG | 2010-01-14 | — | — | US | disclosed |
| EP-1309565-B1 | HETEROCYCLIC MUTILIN ESTERS AND THEIR USE AS ANTIBACTERIALS | SMITHKLINE BEECHAM PLC (GB) | 2008-04-09 | — | — | EP | disclosed |
| US-6878704-B2 | Heterocyclic mutilin esters and their use as antibacterials | SMITHKLINE BEECHAM P.L.C. (GB) | 2005-04-12 | — | — | US | disclosed |
| US-20040058937-A1 | Heterocyclic mutilin esters and their use as antibacterials | SMITHKLINE BEECHAM P.L.C. (GB) | 2004-03-25 | — | — | US | disclosed |
| EP-1309565-A1 | HETEROCYCLIC MUTILIN ESTERS AND THEIR USE AS ANTIBACTERIALS | SMITHKLINE BEECHAM PLC (GB) | 2003-05-14 | — | — | EP | disclosed |
| WO-2002012199-A1 | HETEROCYCLIC MUTILIN ESTERS AND THEIR USE AS ANTIBACTERIALS | SMITHKLINE BEECHAM P.L.C. (GB) | 2002-02-14 | — | — | WO | disclosed |
| EP-0144730-B1 | 2-ANILINO-1,6-DIHYDRO-6-OXO-5-PYRIMIDINECARBOXYLIC ACID DERIVATIVES, PROCESSES FOR THE PREPARATION THEREOF, AND ANTIALLERGIC AGENT CONTAINING THE SAME | MORISHITA PHARMACEUTICAL CO. LTD. (JP) | 1987-07-08 | — | — | EP | disclosed |
| EP-0144730-A1 | 2-Anilino-1,6-dihydro-6-oxo-5-pyrimidinecarboxylic acid derivatives, processes for the preparation thereof, and antiallergic agent containing the same | MORISHITA PHARMACEUTICAL CO. LTD. (JP) | 1985-06-19 | — | — | EP | disclosed |
| JP-S60100559-A | 2-ANILINO-1,6-DIHYDRO-6-OXO-5-PYRIMIDINECARBOXYLIC ACID DERIVATIVE, ITS PREPARATION, AND ANTIALLERGIC CONTAINING IT | MORISHITA SEIYAKU KK | 1985-06-04 | — | — | JP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040058937-A1 | Heterocyclic mutilin esters and their use as antibacterials | MLN, MSH2, MRPL21 | KDM6B 4440/4885KDM4A 3952/4885KDM4D 4508/4885 |
| US-20100010025-A1 | Pyrimidine Derivatives | DPYD, TYMP, TYMS | KDM6B 2681/4885KDM4A 3425/4885KDM4D 2653/4885 |
| US-10364247-B2 | Preparation and use of novel protein kinase inhibitors | MAP3K20, MAP3K19, MAP3K5 | KDM6B 1732/4885KDM4A 2530/4885KDM4D 2649/4885 |
| US-20180105528-A1 | PREPARATION AND USE OF NOVEL PROTEIN KINASE INHIBITORS | MAP3K20, MAP3K19, MAP3K5 | KDM6B 1732/4885KDM4A 2530/4885KDM4D 2649/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.