Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.36 |
| ▸ | ALDH3A1 | P30838 | 6/20 | 0.36 |
| ▸ | ALDH2 | P05091 | 4/20 | 0.36 |
| ▸ | PARG | Q86W56 | 1/20 | 0.35 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.34 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.34 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.33 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.33 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.33 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.33 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.33 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.33 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.33 |
| ▸ | CUL4A | Q13619 | 1/20 | 0.32 |
| ▸ | CES1 | P23141 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26688636 | 0.85 | CHRM1 (0.45) | ALDH1A1ALDH3A1ALDH2PARGCHRM1 | |
| SCHEMBL26688648 | 0.85 | CHRM1 (0.45) | ALDH1A1ALDH3A1ALDH2PARGCHRM1 | |
| SCHEMBL26688697 | 0.85 | PARG (0.40) | PARGCHRM1CHRM3KCNH2CHRM5 | |
| SCHEMBL26688660 | 0.85 | PARG (0.40) | PARGCHRM1CHRM3KCNH2CHRM5 | |
| SCHEMBL31605812 | 0.82 | MAOA (0.35) | ALDH1A1PARGCHRM1CHRM3GABRA1 | |
| SCHEMBL26858136 | 0.81 | CCNC (0.42) | ALDH1A1PARG | |
| SCHEMBL26688633 | 0.80 | PARG (0.57) | PARG | |
| SCHEMBL26858139 | 0.78 | PARG (0.46) | PARG | |
| SCHEMBL30757218 | 0.78 | GABRA1 (0.41) | ALDH1A1ALDH3A1ALDH2GABRA1GABRG2 | |
| SCHEMBL26688630 | 0.78 | GABRA1 (0.41) | ALDH1A1ALDH3A1ALDH2GABRA1GABRG2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2025111492-A1 | INHIBITORS OF PARG | 858 THERAPEUTICS, INC. (US) | 2025-05-30 | — | — | WO | disclosed |