Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 | P11229 | 5/20 | 0.45 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.45 |
| ▸ | PARG | Q86W56 | 1/20 | 0.38 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.37 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.36 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.36 |
| ▸ | CACNA1I | Q9P0X4 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.36 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | PDE4A | P27815 | 1/20 | 0.35 |
| ▸ | DRD2 | P14416 | 2/20 | 0.34 |
| ▸ | HTR6 | P50406 | 2/20 | 0.34 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.34 |
| ▸ | HRH1 | P35367 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.34 |
| ▸ | HTR1A | P08908 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26688636 | 1.00 | CHRM1 (0.45) | CHRM1CHRM3PARGCHRM5CACNA1G | |
| SCHEMBL31605951 | 0.85 | ACHE (0.37) | CHRM1CHRM3PARGCHRM5GABRA1 | |
| SCHEMBL31605812 | 0.83 | MAOA (0.35) | CHRM1CHRM3PARGGABRA1GABRA5 | |
| SCHEMBL26688697 | 0.82 | PARG (0.40) | CHRM1CHRM3PARGCHRM5KCNH2 | |
| SCHEMBL26688660 | 0.82 | PARG (0.40) | CHRM1CHRM3PARGCHRM5KCNH2 | |
| SCHEMBL26858136 | 0.79 | CCNC (0.42) | PARGMEN1KMT2AALDH1A1 | |
| SCHEMBL26688633 | 0.77 | PARG (0.57) | PARG | |
| SCHEMBL11877884 | 0.77 | ALDH1A1 (0.49) | CHRM1CACNA1GCACNA1HCACNA1ITSHR | |
| SCHEMBL26858139 | 0.76 | PARG (0.46) | PARG | |
| SCHEMBL31605742 | 0.76 | PARG (0.49) | PARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023224998-A1 | INHIBITORS OF PARG | 858 THERAPEUTICS, INC. (US) | 2023-11-23 | — | — | WO | disclosed |