Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 1/20 | 0.62 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.62 |
| ▸ | BCR | P11274 | 1/20 | 0.62 |
| ▸ | TOP2A | P11388 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.50 |
| ▸ | STK17B | O94768 | 3/20 | 0.49 |
| ▸ | IKBKB | O14920 | 1/20 | 0.49 |
| ▸ | AURKA | O14965 | 1/20 | 0.49 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.49 |
| ▸ | GSK3B | P49841 | 1/20 | 0.49 |
| ▸ | BLK | P51451 | 1/20 | 0.49 |
| ▸ | BTK | Q06187 | 1/20 | 0.49 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.49 |
| ▸ | DAPK2 | Q9UIK4 | 1/20 | 0.49 |
| ▸ | TUBB1 | Q9H4B7 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.46 |
| ▸ | CXCL12 | P48061 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3160973 | 1.00 | ABL1 (0.62) | ABL1ABCB1BCRTOP2AALDH1A1 | |
| SCHEMBL5974346 | 0.91 | NFE2L2 (0.62) | ABCB1TOP2AALDH1A1NFE2L2GSK3B | |
| SCHEMBL5974352 | 0.91 | NFE2L2 (0.62) | ABCB1TOP2AALDH1A1NFE2L2GSK3B | |
| SCHEMBL3157397 | 0.88 | TUBB1 (0.49) | ABL1ABCB1BCRALDH1A1TUBB1 | |
| SCHEMBL3157383 | 0.88 | TUBB1 (0.49) | ABL1ABCB1BCRALDH1A1TUBB1 | |
| SCHEMBL3160398 | 0.82 | TUBB4A (0.59) | ALDH1A1NFE2L2TUBB1MAPTPTGS1 | |
| SCHEMBL3160404 | 0.82 | TUBB4A (0.59) | ALDH1A1NFE2L2TUBB1MAPTPTGS1 | |
| SCHEMBL5974745 | 0.81 | CXCL12 (0.55) | ABCB1TOP2AALDH1A1NFE2L2GSK3B | |
| SCHEMBL5974751 | 0.81 | CXCL12 (0.55) | ABCB1TOP2AALDH1A1NFE2L2GSK3B | |
| SCHEMBL827716 | 0.80 | NFE2L2 (0.51) | ABL1ABCB1BCRALDH1A1NFE2L2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1328511-B1 | SUBSTITUTED (E)-STYRYL BENZYLSULFONES FOR TREATING PROLIFERATIVE DISORDERS | UNIV TEMPLE (US) | 2010-03-24 | — | — | EP | disclosed |
| US-7053123-B2 | Substituted (e)-styryl benzylsulfones for treating proliferative disorders | TEMPLE UNIVERSITY-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2006-05-30 | — | — | US | disclosed |
| EP-1328511-A4 | SUBSTITUTED (E)-STYRYL BENZYLSULFONES FOR TREATING PROLIFERATIVE DISORDERS | UNIV TEMPLE (US) | 2005-11-30 | — | — | EP | disclosed |
| US-20050101528-A1 | Substituted (e)-styryl benzylsulfones for treating proliferative disorders | TEMPLE UNIVERSITY - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION | 2005-05-12 | — | — | US | disclosed |
| EP-1328511-A1 | SUBSTITUTED (E)-STYRYL BENZYLSULFONES FOR TREATING PROLIFERATIVE DISORDERS | Temple University of the Commonwealth System of Higher Education (US) | 2003-07-23 | — | — | EP | disclosed |
| WO-2002028828-A1 | SUBSTITUTED (E)-STYRYL BENZYLSULFONES FOR TREATING PROLIFERATIVE DISORDERS | TEMPLE UNIVERSITY - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2002-04-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050101528-A1 | Substituted (e)-styryl benzylsulfones for treating proliferative disorders | CCNO, HCCS, CCNT1 | ABL1 595/4885ABCB1 3258/4885BCR 1502/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.