Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NFE2L2 | Q16236 | 3/20 | 0.62 |
| ▸ | ALOX5 | P09917 | 3/20 | 0.57 |
| ▸ | CXCL12 | P48061 | 1/20 | 0.55 |
| ▸ | BACE1 | P56817 | 3/20 | 0.54 |
| ▸ | TTR | P02766 | 1/20 | 0.52 |
| ▸ | APP | P05067 | 7/20 | 0.52 |
| ▸ | MAPT | P10636 | 4/20 | 0.52 |
| ▸ | ACHE | P22303 | 1/20 | 0.52 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.51 |
| ▸ | TSHR | P16473 | 2/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.51 |
| ▸ | TYR | P14679 | 2/20 | 0.51 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.51 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.51 |
| ▸ | STAT3 | P40763 | 2/20 | 0.51 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.51 |
| ▸ | RELA | Q04206 | 2/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5974346 | 1.00 | NFE2L2 (0.62) | NFE2L2ALOX5CXCL12BACE1TTR | |
| SCHEMBL3160973 | 0.91 | ABL1 (0.62) | NFE2L2ALOX5CXCL12BACE1MAPT | |
| SCHEMBL3160982 | 0.91 | ABL1 (0.62) | NFE2L2ALOX5CXCL12BACE1MAPT | |
| SCHEMBL5974751 | 0.90 | CXCL12 (0.55) | NFE2L2ALOX5CXCL12BACE1TTR | |
| SCHEMBL5974745 | 0.90 | CXCL12 (0.55) | NFE2L2ALOX5CXCL12BACE1TTR | |
| SCHEMBL3160398 | 0.88 | TUBB4A (0.59) | NFE2L2TTRMAPTCYP2D6CYP2C9 | |
| SCHEMBL3160404 | 0.88 | TUBB4A (0.59) | NFE2L2TTRMAPTCYP2D6CYP2C9 | |
| SCHEMBL28713934 | 0.85 | TUBB1 (0.55) | NFE2L2ALOX5BACE1TTRAPP | |
| SCHEMBL28713935 | 0.85 | TUBB1 (0.55) | NFE2L2ALOX5BACE1TTRAPP | |
| SCHEMBL3165273 | 0.85 | BACE1 (0.45) | NFE2L2BACE1TTRKDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1379228-A4 | (Z)-STYRYLBENZYLSULFONES AND PHARMACEUTICAL USES THEREOF | UNIV TEMPLE (US) | 2006-01-04 | — | — | EP | disclosed |
| US-6833480-B2 | Useful in inhibiting proliferation of and/or killing cancer cells | TEMPLE UNIVERSITY - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION | 2004-12-21 | — | — | US | disclosed |
| US-20040133030-A1 | (Z)-styrylbenzylsulfones and pharmaceutical uses thereof | TEMPLE UNIVERSITY - OF THE COMMOWEALTH SYSTEM OF HIGHER EDUCATION | 2004-07-08 | — | — | US | disclosed |
| EP-1379228-A1 | (Z)-STYRYLBENZYLSULFONES AND PHARMACEUTICAL USES THEREOF | Temple University of the Commonwealth System of Higher Education (US) | 2004-01-14 | — | — | EP | disclosed |
| WO-2002067913-A8 | (Z)-STYRYLBENZYLSULFONES AND PHARMACEUTICAL USES THEREOF | UNIV TEMPLE (US) | 2002-11-14 | — | — | WO | disclosed |
| WO-2002067913-A1 | (Z)-STYRYLBENZYLSULFONES AND PHARMACEUTICAL USES THEREOF | TEMPLE UNIVERSITY-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2002-09-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040133030-A1 | (Z)-styrylbenzylsulfones and pharmaceutical uses thereof | STS, ST14, TP53 | NFE2L2 1846/4885ALOX5 2803/4885CXCL12 1357/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.