Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.44 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 7/20 | 0.41 |
| ▸ | ENPP2 | Q13822 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.40 |
| ▸ | HTT | P42858 | 4/20 | 0.40 |
| ▸ | MET | P08581 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 5/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | HTR1A | P08908 | 1/20 | 0.38 |
| ▸ | HTR1D | P28221 | 1/20 | 0.38 |
| ▸ | HTR1B | P28222 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3155589 | 0.93 | SIGMAR1 (0.47) | HRH4SIGMAR1LMNAALDH1A1HTT | |
| SCHEMBL3163575 | 0.92 | POLB (0.44) | HRH4LMNAENPP2ALDH1A1HTT | |
| SCHEMBL3163437 | 0.89 | LMNA (0.54) | HRH4LMNAALDH1A1HTTMAPT | |
| SCHEMBL3166539 | 0.88 | POLB (0.43) | HRH4LMNAALDH1A1HTTSMN1; SMN2 | |
| SCHEMBL3164879 | 0.88 | GBA1 (0.48) | HRH4LMNAALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL3165234 | 0.88 | MEN1 (0.47) | SIGMAR1MAPTPOLBMEN1KMT2A | |
| SCHEMBL3177354 | 0.85 | KMT2A (0.49) | SIGMAR1LMNAALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL3164902 | 0.85 | GFER (0.47) | HRH4LMNAALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL3166615 | 0.84 | MGLL (0.45) | LMNAALDH1A1HTTMAPTSMN1; SMN2 | |
| SCHEMBL3164771 | 0.84 | SMN1; SMN2 (0.44) | HRH4LMNAMAPTSMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1465631-B1 | PYRIMIDINE A2B SELECTIVE ANTAGONIST COMPOUNDS, THEIR SYNTHESIS AND USE | OSI PHARM INC (US) | 2010-02-24 | — | — | EP | disclosed |