Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DDB1 | Q16531 | 7/20 | 0.47 |
| ▸ | CRBN | Q96SW2 | 7/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.43 |
| ▸ | MMP13 | P45452 | 2/20 | 0.42 |
| ▸ | ADAMTS5 | Q9UNA0 | 2/20 | 0.42 |
| ▸ | MMP2 | P08253 | 1/20 | 0.42 |
| ▸ | MMP14 | P50281 | 1/20 | 0.42 |
| ▸ | GPR119 | Q8TDV5 | 5/20 | 0.41 |
| ▸ | F13A1 | P00488 | 1/20 | 0.39 |
| ▸ | TGM2 | P21980 | 1/20 | 0.39 |
| ▸ | TGM1 | P22735 | 1/20 | 0.39 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.39 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.39 |
| ▸ | NAMPT | P43490 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30703627 | 0.85 | DDB1 (0.48) | DDB1CRBNMAPTALDH1A1LMNA | |
| SCHEMBL31630927 | 0.84 | DDB1 (0.49) | DDB1CRBNMAPTALDH1A1LMNA | |
| SCHEMBL22119507 | 0.83 | DDB1 (0.59) | DDB1CRBNMAPTALDH1A1LMNA | |
| SCHEMBL29265203 | 0.81 | CRBN (0.55) | DDB1CRBNMAPTALDH1A1LMNA | |
| SCHEMBL30525413 | 0.81 | CRBN (0.55) | DDB1CRBNMAPTALDH1A1LMNA | |
| SCHEMBL30952388 | 0.79 | DDB1 (0.50) | DDB1CRBNMAPTALDH1A1LMNA | |
| SCHEMBL15754287 | 0.79 | ALDH1A1 (0.52) | MAPTALDH1A1LMNAPDK2GPR119 | |
| SCHEMBL20140111 | 0.78 | MAPT (0.54) | MAPTALDH1A1LMNAPDK2GPR119 | |
| SCHEMBL30643667 | 0.78 | DDB1 (0.49) | DDB1CRBNMAPTALDH1A1LMNA | |
| SCHEMBL25034753 | 0.77 | DDB1 (0.48) | DDB1CRBNMAPTALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250197411-A1 | IRAK4 PROTACS | ASTRAZENECA AB (SE) | 2025-06-19 | — | — | US | disclosed |
| WO-2025125575-A1 | IRAK4 PROTACS | ASTRAZENECA AB (SE) | 2025-06-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250197411-A1 | IRAK4 PROTACS | IRAK4, IRAK2, IRAK3 | DDB1 750/4885CRBN 94/4885MAPT 1623/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.