Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 1/20 | 0.46 |
| ▸ | JAK1 | P23458 | 1/20 | 0.46 |
| ▸ | TYK2 | P29597 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | NNMT | P40261 | 1/20 | 0.40 |
| ▸ | PIK3C3 | Q8NEB9 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | CNR2 | P34972 | 1/20 | 0.39 |
| ▸ | AAK1 | Q2M2I8 | 5/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.37 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31627741 | 0.81 | JAK2 (0.46) | JAK2JAK1TYK2RAB9ACYP3A4 | |
| SCHEMBL13893650 | 0.79 | KDR (0.47) | RAB9ACYP3A4NPC1CYP1A2CYP2C19 | |
| SCHEMBL9890532 | 0.79 | PIK3C3 (0.40) | JAK2JAK1TYK2RAB9ACYP3A4 | |
| SCHEMBL31627634 | 0.78 | JAK2 (0.44) | JAK2JAK1TYK2RAB9ACYP3A4 | |
| SCHEMBL31627729 | 0.77 | JAK2 (0.43) | JAK2JAK1TYK2RAB9ACYP3A4 | |
| SCHEMBL31627922 | 0.76 | JAK2 (0.42) | JAK2JAK1TYK2RAB9ACYP3A4 | |
| SCHEMBL31627881 | 0.76 | CHEK1 (0.46) | JAK2JAK1TYK2RAB9ANPC1 | |
| SCHEMBL21508686 | 0.73 | L3MBTL1 (0.50) | JAK2JAK1TYK2NPC1PIK3C3 | |
| SCHEMBL20031484 | 0.70 | PTK2 (0.53) | JAK2JAK1TYK2RAB9ANPC1 | |
| SCHEMBL16705406 | 0.70 | JAK2 (0.55) | JAK2JAK1TYK2CYP3A4TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250236609-A1 | VPS34 INHIBITORS AND METHODS OF USE THEREOF | DECIPHERA PHARMACEUTICALS, LLC | 2025-07-24 | — | — | US | disclosed |
| WO-2025129019-A1 | VPS34 INHIBITORS AND METHODS OF USE THEREOF | DECIPHERA PHARMACEUTICALS, LLC (US) | 2025-06-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250236609-A1 | VPS34 INHIBITORS AND METHODS OF USE THEREOF | VPS35, VPS28, VPS26B | JAK2 1725/4885JAK1 690/4885TYK2 1342/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.