Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LDHA | P00338 | 2/20 | 0.72 |
| ▸ | AXL | P30530 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 2/20 | 0.49 |
| ▸ | PLA2G2A | P14555 | 2/20 | 0.48 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.47 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.47 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.46 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.46 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.46 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.45 |
| ▸ | HPGD | P15428 | 4/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 3/20 | 0.44 |
| ▸ | RAB9A | P51151 | 3/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29141529 | 0.88 | LDHA (0.59) | LDHAAXLGAAPLA2G2APDE4B | |
| SCHEMBL31636902 | 0.85 | LDHA (0.52) | LDHAGABRA5ALDH1A1HPGDNPC1 | |
| SCHEMBL25148607 | 0.84 | LDHA (0.54) | LDHAAXLGAAPLA2G2APDE4B | |
| SCHEMBL30364708 | 0.84 | LDHA (0.54) | LDHAAXLGAAPLA2G2APDE4B | |
| SCHEMBL18924640 | 0.82 | LDHA (0.63) | LDHAGAAALDH1A1KDM4EHPGD | |
| SCHEMBL31636729 | 0.80 | LDHA (0.50) | LDHAAXLGAAPLA2G2APDE4B | |
| SCHEMBL30930671 | 0.79 | AXL (0.53) | LDHAAXLBAZ2BKDM4EMEN1 | |
| SCHEMBL2715851 | 0.76 | LDHA (0.67) | LDHABAZ2BGABRG2GABRB3GABRA5 | |
| SCHEMBL30930704 | 0.76 | NPC1 (0.54) | LDHAAXLPLA2G2AMAPTSLC2A1 | |
| SCHEMBL27285124 | 0.76 | NPC1 (0.54) | LDHAAXLPLA2G2AMAPTSLC2A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2025137158-A1 | DERIVATIVES OF ([1,2,4]TRIAZOLO[5,1-A]ISOQUINOLINE-5-CARBONYL)GLYCINATE AS PHD INHIBITOR COMPOUNDS, COMPOSITIONS, AND METHODS OF USE | AKEBIA THERAPEUTICS, INC. (US) | 2025-06-26 | — | — | WO | disclosed |