Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LDHA | P00338 | 1/20 | 0.54 |
| ▸ | AXL | P30530 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 2/20 | 0.48 |
| ▸ | PLA2G2A | P14555 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.47 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.47 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.45 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.45 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.45 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | SMO | Q99835 | 1/20 | 0.44 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25148607 | 1.00 | LDHA (0.54) | LDHAAXLGAAPLA2G2AKDM4E | |
| SCHEMBL31636734 | 0.84 | LDHA (0.72) | LDHAAXLGAAPLA2G2AKDM4E | |
| SCHEMBL29367948 | 0.83 | MAPT (0.46) | GAAPLA2G2AKDM4ESLC6A4SLC6A3 | |
| SCHEMBL22712485 | 0.83 | MAPT (0.46) | GAAPLA2G2AKDM4ESLC6A4SLC6A3 | |
| SCHEMBL16635454 | 0.82 | CFTR (0.47) | GAAKMT2ASMN1; SMN2MAPTLMNA | |
| SCHEMBL29141529 | 0.81 | LDHA (0.59) | LDHAAXLGAAPLA2G2AKDM4E | |
| SCHEMBL31636729 | 0.79 | LDHA (0.50) | LDHAAXLGAAPLA2G2AKDM4E | |
| SCHEMBL3342506 | 0.79 | KMO (0.48) | LDHASLC6A4SLC6A3SMN1; SMN2MAPT | |
| SCHEMBL16635658 | 0.79 | MAPT (0.43) | GAAMAPTPDK2 | |
| SCHEMBL1327000 | 0.78 | MRGPRX4 (0.40) | KDM4ESLC6A4SLC6A3MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023062575-A1 | CYCLIC VINYL SULFONE COMPOUNDS AS WRN INHIBITORS | IDEAYA BIOSCIENCES, INC. (US) | 2023-04-20 | — | — | WO | disclosed |