Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.36 |
| ▸ | SLC27A1 | Q6PCB7 | 6/20 | 0.35 |
| ▸ | MAPT | P10636 | 4/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | RORC | P51449 | 2/20 | 0.35 |
| ▸ | DHODH | Q02127 | 2/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.33 |
| ▸ | PSEN1 | P49768 | 2/20 | 0.33 |
| ▸ | PSEN2 | P49810 | 2/20 | 0.33 |
| ▸ | APH1B | Q8WW43 | 2/20 | 0.33 |
| ▸ | NCSTN | Q92542 | 2/20 | 0.33 |
| ▸ | APH1A | Q96BI3 | 2/20 | 0.33 |
| ▸ | PSENEN | Q9NZ42 | 2/20 | 0.33 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.33 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3164089 | 0.79 | POLB (0.47) | LMNAMAPTALDH1A1 | |
| SCHEMBL3157384 | 0.79 | CNR1 (0.40) | LMNAMAPTALDH1A1 | |
| SCHEMBL3163673 | 0.78 | KCNQ2 (0.44) | LMNASLC27A1MAPTNPC1ALDH1A1 | |
| SCHEMBL3172485 | 0.77 | LMNA (0.43) | LMNAMAPTNPC1ALDH1A1TP53 | |
| SCHEMBL3164398 | 0.75 | HRH3 (0.38) | LMNASLC27A1MAPTALDH1A1THRB | |
| SCHEMBL4797365 | 0.69 | NPY5R (0.37) | MAPTALDH1A1TP53NPY5R | |
| SCHEMBL3162896 | 0.68 | NPC1 (0.54) | LMNASLC27A1MAPTNPC1ALDH1A1 | |
| SCHEMBL3163269 | 0.68 | DRD2 (0.40) | LMNASLC27A1MAPTNPC1ALDH1A1 | |
| SCHEMBL3172493 | 0.67 | MAPT (0.43) | LMNASLC27A1MAPTNPC1ALDH1A1 | |
| SCHEMBL3164126 | 0.66 | KDM4E (0.46) | LMNASLC27A1MAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1716128-B1 | SUBSTITUTED 4,5,6,7-TETRAHYDRO-BENZOTHIAZOL-2-YLAMINE COMPOUNDS | GRUENENTHAL GMBH (DE) | 2010-03-31 | — | — | EP | claimed |