Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 4/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | PSEN1 | P49768 | 3/20 | 0.38 |
| ▸ | PSEN2 | P49810 | 3/20 | 0.38 |
| ▸ | APH1B | Q8WW43 | 3/20 | 0.38 |
| ▸ | NCSTN | Q92542 | 3/20 | 0.38 |
| ▸ | APH1A | Q96BI3 | 3/20 | 0.38 |
| ▸ | PSENEN | Q9NZ42 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.38 |
| ▸ | PTBP1 | P26599 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.38 |
| ▸ | RELA | Q04206 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3164398 | 0.81 | HRH3 (0.38) | LMNATHRBMAPTALDH1A1 | |
| SCHEMBL3157384 | 0.80 | CNR1 (0.40) | LMNAMAPTALDH1A1HTTGLS | |
| SCHEMBL3166107 | 0.78 | SMN1; SMN2 (0.65) | LMNATHRBMAPTALDH1A1TP53 | |
| SCHEMBL3172964 | 0.78 | PARP1 (0.47) | LMNAMAPTALDH1A1NPC1RAB9A | |
| SCHEMBL3172349 | 0.77 | ADORA3 (0.50) | LMNAMAPTALDH1A1TP53NPC1 | |
| SCHEMBL3164100 | 0.77 | LMNA (0.36) | LMNATHRBMAPTALDH1A1TP53 | |
| SCHEMBL3163684 | 0.77 | MAPT (0.41) | LMNAMAPTALDH1A1TP53NPC1 | |
| SCHEMBL3163907 | 0.77 | NPC1 (0.50) | LMNAALDH1A1NPC1RAB9AMEN1 | |
| SCHEMBL3164089 | 0.76 | POLB (0.47) | LMNAMAPTALDH1A1MEN1KMT2A | |
| SCHEMBL3166048 | 0.75 | CSNK1D (0.51) | LMNATHRBMAPTALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1716128-B1 | SUBSTITUTED 4,5,6,7-TETRAHYDRO-BENZOTHIAZOL-2-YLAMINE COMPOUNDS | GRUENENTHAL GMBH (DE) | 2010-03-31 | — | — | EP | claimed |