Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | BACE1 | P56817 | 1/20 | 0.37 |
| ▸ | CLPP | Q16740 | 4/20 | 0.37 |
| ▸ | NOS3 | P29474 | 3/20 | 0.36 |
| ▸ | NOS1 | P29475 | 3/20 | 0.36 |
| ▸ | NOS2 | P35228 | 3/20 | 0.36 |
| ▸ | TAS1R3 | Q7RTX0 | 2/20 | 0.36 |
| ▸ | TAS1R1 | Q7RTX1 | 2/20 | 0.36 |
| ▸ | PSMB5 | P28074 | 3/20 | 0.36 |
| ▸ | PSMB1 | P20618 | 2/20 | 0.36 |
| ▸ | PSMB2 | P49721 | 2/20 | 0.36 |
| ▸ | LONP1 | P36776 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | APEX1 | P27695 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12754545 | 1.00 | MAPT (0.38) | MAPTMAPK1TDP1BACE1CLPP | |
| SCHEMBL12754450 | 0.93 | BACE1 (0.37) | MAPTBACE1CLPPNOS3NOS1 | |
| SCHEMBL3155402 | 0.91 | ALDH1A1 (0.40) | MAPTCLPPPSMB5PSMB1PSMB2 | |
| SCHEMBL15291187 | 0.89 | NOS3 (0.39) | BACE1CLPPNOS3NOS1NOS2 | |
| SCHEMBL3168342 | 0.88 | PSMB5 (0.42) | CLPPPSMB5PSMB1PSMB2 | |
| SCHEMBL608977 | 0.87 | MAPT (0.39) | MAPTMAPK1TDP1NOS3NOS1 | |
| SCHEMBL12754443 | 0.85 | LONP1 (0.36) | CLPPPSMB5PSMB1PSMB2LONP1 | |
| SCHEMBL3164560 | 0.85 | PSMB5 (0.38) | CLPPNOS3NOS1NOS2PSMB5 | |
| SCHEMBL10245061 | 0.85 | SMN1; SMN2 (0.41) | MAPTMAPK1CLPPTAS1R3TAS1R1 | |
| SCHEMBL608976 | 0.84 | LMNA (0.39) | MAPTMAPK1TDP1NOS3NOS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1660507-B9 | PROTEASOME INHIBITORS AND METHODS OF USING THE SAME | CEPHALON INC (US) | 2010-03-24 | — | — | EP | claimed |
| EP-1660507-B1 | PROTEASOME INHIBITORS AND METHODS OF USING THE SAME | CEPHALON INC (US) | 2009-08-05 | — | — | EP | claimed |