Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 12/20 | 0.67 |
| ▸ | CAPN1 | P07384 | 2/20 | 0.66 |
| ▸ | CTSL | P07711 | 7/20 | 0.64 |
| ▸ | CTSB | P07858 | 4/20 | 0.64 |
| ▸ | CTSS | P25774 | 3/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7740137 | 0.91 | CAPN1 (0.69) | CTSKCAPN1CTSLCTSBCTSS | |
| SCHEMBL8407401 | 0.89 | CTSK (0.65) | CTSKCAPN1CTSLCTSBCTSS | |
| SCHEMBL7164724 | 0.89 | CTSK (0.67) | CTSKCAPN1CTSLCTSBCTSS | |
| SCHEMBL21485271 | 0.88 | CTSK (0.70) | CTSKCAPN1CTSLCTSBCTSS | |
| SCHEMBL27509913 | 0.86 | CTSK (0.70) | CTSKCAPN1CTSLCTSBCTSS | |
| SCHEMBL27509912 | 0.86 | CTSK (0.70) | CTSKCAPN1CTSLCTSBCTSS | |
| SCHEMBL25406813 | 0.86 | CTSK (0.77) | CTSKCAPN1CTSLCTSBCTSS | |
| SCHEMBL20770085 | 0.86 | CTSK (0.77) | CTSKCAPN1CTSLCTSBCTSS | |
| SCHEMBL4872585 | 0.86 | CTSK (0.77) | CTSKCAPN1CTSLCTSBCTSS | |
| SCHEMBL8823918 | 0.86 | CTSK (0.77) | CTSKCAPN1CTSLCTSBCTSS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1276895-B1 | METHOD FOR THE IDENTIFICATION OF ACTIVE SITE PROTEASE INACTIVATORS | UNIV GEORGIA (US) | 2010-03-17 | — | — | EP | disclosed |
| US-20080139458-A1 | Lubricating a joint in a mammal by administering lubricin and an enzyme inhibitor like Z-Leu-Leu-Leu-fluoromethyl ketone (Z-LLL-FMK) | MUCOSAL THERAPEUTICS | 2008-06-12 | — | — | US | disclosed |
| EP-1379634-A1 | ACTIVE SITE INACTIVATORS | UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC. (US) | 2004-01-14 | — | — | EP | disclosed |
| US-20030077653-A1 | Method for the identification of active site protease inactivators | THE UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC. | 2003-04-24 | — | — | US | disclosed |
| EP-1276895-A2 | METHOD FOR THE IDENTIFICATION OF ACTIVE SITE PROTEASE INACTIVATORS | UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC. (US) | 2003-01-22 | — | — | EP | disclosed |
| WO-2002086115-A1 | ACTIVE SITE INACTIVATORS | THE UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC. (US) | 2002-10-31 | — | — | WO | disclosed |
| WO-2001081613-A2 | METHOD FOR THE IDENTIFICATION OF ACTIVE SITE PROTEASE INACTIVATORS | THE UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC. (US) | 2001-11-01 | — | — | WO | disclosed |