Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 11/20 | 0.49 |
| ▸ | OPRL1 | P41146 | 8/20 | 0.49 |
| ▸ | SCN1A | P35498 | 1/20 | 0.48 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.48 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.48 |
| ▸ | OPRD1 | P41143 | 5/20 | 0.44 |
| ▸ | OPRK1 | P41145 | 4/20 | 0.44 |
| ▸ | HTR1A | P08908 | 3/20 | 0.44 |
| ▸ | DRD2 | P14416 | 3/20 | 0.44 |
| ▸ | DRD1 | P21728 | 3/20 | 0.44 |
| ▸ | DRD4 | P21917 | 3/20 | 0.44 |
| ▸ | DRD5 | P21918 | 3/20 | 0.44 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.44 |
| ▸ | HRH2 | P25021 | 3/20 | 0.44 |
| ▸ | HTR1D | P28221 | 3/20 | 0.44 |
| ▸ | HTR2A | P28223 | 3/20 | 0.44 |
| ▸ | HTR2C | P28335 | 3/20 | 0.44 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.44 |
| ▸ | HTR7 | P34969 | 3/20 | 0.44 |
| ▸ | DRD3 | P35462 | 3/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3163863 | 0.88 | POLB (0.45) | OPRM1OPRL1SCN1ASCN2ASCN3A | |
| SCHEMBL3172100 | 0.87 | OPRL1 (0.49) | OPRM1OPRL1OPRD1OPRK1DRD4 | |
| SCHEMBL3165134 | 0.87 | ALDH1A1 (0.48) | ALDH1A1LMNAMAPK1HTTSMN1; SMN2 | |
| SCHEMBL3169426 | 0.85 | POLB (0.45) | DRD2DRD4DRD3ALDH1A1LMNA | |
| SCHEMBL3170318 | 0.80 | LMNA (0.42) | OPRD1ALDH1A1MAPTLMNACYP1A2 | |
| SCHEMBL3161434 | 0.80 | ADORA1 (0.42) | ALDH1A1LMNAMAPK1HTTSMN1; SMN2 | |
| SCHEMBL3162879 | 0.79 | UTS2R (0.44) | DRD2SLC6A2HTR2AHTR2CSLC6A4 | |
| SCHEMBL3163125 | 0.78 | NPC1 (0.47) | ALDH1A1MAPTNPSR1 | |
| SCHEMBL3164709 | 0.78 | NPC1 (0.47) | ALDH1A1MAPTNPSR1 | |
| SCHEMBL3156278 | 0.78 | ALDH1A1 (0.44) | ALDH1A1MAPTLMNACYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1465631-B1 | PYRIMIDINE A2B SELECTIVE ANTAGONIST COMPOUNDS, THEIR SYNTHESIS AND USE | OSI PHARM INC (US) | 2010-02-24 | — | — | EP | disclosed |