Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | ADORA1 | P30542 | 8/20 | 0.40 |
| ▸ | ADORA3 | P0DMS8 | 8/20 | 0.40 |
| ▸ | ADORA2A | P29274 | 6/20 | 0.40 |
| ▸ | ADORA2B | P29275 | 3/20 | 0.40 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3165134 | 0.90 | ALDH1A1 (0.48) | LMNAMEN1KMT2APOLBADORA1 | |
| SCHEMBL3162386 | 0.87 | OPRD1 (0.46) | ADORA1ADORA3ADORA2AADORA2BOPRD1 | |
| SCHEMBL3164709 | 0.86 | NPC1 (0.47) | MEN1KMT2APOLBMAPTADORA1 | |
| SCHEMBL3163125 | 0.86 | NPC1 (0.47) | MEN1KMT2APOLBMAPTADORA1 | |
| SCHEMBL3171920 | 0.85 | ADORA1 (0.47) | ADORA1ADORA3ADORA2AADORA2BALDH1A1 | |
| SCHEMBL3162879 | 0.85 | UTS2R (0.44) | ADORA1ADORA3ADORA2AADORA2B | |
| SCHEMBL3169426 | 0.85 | POLB (0.45) | LMNAPOLBADORA1ADORA3ADORA2A | |
| SCHEMBL3163863 | 0.85 | POLB (0.45) | LMNAMEN1KMT2APOLBMAPT | |
| SCHEMBL3164858 | 0.84 | ALDH1A1 (0.49) | LMNAMAPTADORA1ADORA2AALDH1A1 | |
| SCHEMBL3163144 | 0.84 | ADORA3 (0.46) | LMNAMEN1KMT2APOLBMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1465631-B1 | PYRIMIDINE A2B SELECTIVE ANTAGONIST COMPOUNDS, THEIR SYNTHESIS AND USE | OSI PHARM INC (US) | 2010-02-24 | — | — | EP | disclosed |