Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.57 |
| ▸ | RAB9A | P51151 | 2/20 | 0.57 |
| ▸ | LTA4H | P09960 | 2/20 | 0.54 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | CCR5 | P51681 | 1/20 | 0.47 |
| ▸ | S1PR5 | Q9H228 | 2/20 | 0.47 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3164353 | 0.86 | MAPT (0.63) | LTA4HSMN1; SMN2KDM4EALDH1A1KMT2A | |
| SCHEMBL3164156 | 0.82 | LTA4H (0.50) | NPC1RAB9ALTA4HSMN1; SMN2KDM4E | |
| SCHEMBL6286609 | 0.81 | GAA (0.63) | NPC1RAB9ALTA4HKDM4EALDH1A1 | |
| SCHEMBL6284121 | 0.81 | GAA (0.63) | NPC1RAB9ALTA4HKDM4EALDH1A1 | |
| SCHEMBL2450749 | 0.81 | GAA (0.63) | NPC1RAB9ALTA4HKDM4EALDH1A1 | |
| SCHEMBL3172406 | 0.80 | CCR5 (0.51) | ALDH1A1KMT2AMEN1CCR5DPP7 | |
| SCHEMBL11255291 | 0.78 | LTA4H (0.58) | LTA4HKDM4EALDH1A1KMT2AMEN1 | |
| SCHEMBL2448741 | 0.76 | KDM4E (0.71) | SMN1; SMN2KDM4EALDH1A1KMT2AMEN1 | |
| SCHEMBL2733992 | 0.76 | BACE1 (0.51) | KMT2AMEN1 | |
| SCHEMBL16673662 | 0.75 | KDM4E (0.58) | SMN1; SMN2KDM4EALDH1A1KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1716128-B1 | SUBSTITUTED 4,5,6,7-TETRAHYDRO-BENZOTHIAZOL-2-YLAMINE COMPOUNDS | GRUENENTHAL GMBH (DE) | 2010-03-31 | — | — | EP | claimed |