Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RET | P07949 | 10/20 | 0.36 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.34 |
| ▸ | GRM4 | Q14833 | 3/20 | 0.34 |
| ▸ | JAK2 | O60674 | 1/20 | 0.34 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.33 |
| ▸ | ERN1 | O75460 | 1/20 | 0.33 |
| ▸ | STK10 | O94804 | 1/20 | 0.33 |
| ▸ | MAP3K6 | O95382 | 1/20 | 0.33 |
| ▸ | ABL1 | P00519 | 1/20 | 0.33 |
| ▸ | ESR1 | P03372 | 1/20 | 0.33 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.33 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.33 |
| ▸ | KIT | P10721 | 1/20 | 0.33 |
| ▸ | BCR | P11274 | 1/20 | 0.33 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.33 |
| ▸ | NQO2 | P16083 | 1/20 | 0.33 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.33 |
| ▸ | FLT1 | P17948 | 1/20 | 0.33 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.33 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31661888 | 0.90 | RET (0.36) | RETIRAK4GRM4AXL | |
| SCHEMBL31662165 | 0.83 | IRAK4 (0.37) | RETIRAK4JAK2JAK1JAK3 | |
| SCHEMBL31661957 | 0.80 | IRAK4 (0.36) | IRAK4JAK2FGFR1FGFR2FGFR3 | |
| SCHEMBL31661929 | 0.79 | IRAK4 (0.37) | RETIRAK4JAK2JAK1JAK3 | |
| SCHEMBL31662162 | 0.79 | IRAK4 (0.37) | RETIRAK4JAK2JAK1JAK3 | |
| SCHEMBL31662279 | 0.79 | IRAK4 (0.37) | RETIRAK4JAK2JAK1JAK3 | |
| SCHEMBL31662135 | 0.79 | IRAK4 (0.37) | RETIRAK4JAK2JAK1JAK3 | |
| SCHEMBL31661983 | 0.78 | CNR2 (0.32) | RETIRAK4PDGFRBPDGFRAJAK1 | |
| SCHEMBL31662142 | 0.77 | IRAK4 (0.39) | IRAK4 | |
| SCHEMBL31662113 | 0.77 | SCN9A (0.39) | IRAK4ROCK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2025149545-A1 | HETEROARYLPHENYL ETHER DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2025-07-17 | — | — | WO | claimed |
| WO-2025149545-A1 | HETEROARYLPHENYL ETHER DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2025-07-17 | — | — | WO | disclosed |