Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Doxribtimine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TK1 | P04183 | 4/20 | 0.52 |
| ▸ | LMNA | P02545 | 3/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 2/20 | 0.51 |
| ▸ | TK2 | O00142 | 1/20 | 0.51 |
| ▸ | ALB | P02768 | 1/20 | 0.51 |
| ▸ | PKM | P14618 | 1/20 | 0.51 |
| ▸ | BLM | P54132 | 1/20 | 0.51 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Doxribtimine SCHEMBL1052084 | 1.00 | TK1 (0.52) | TK1LMNASMN1; SMN2TSHRTK2 | |
| Doxribtimine SCHEMBL3155784 | 1.00 | TK1 (0.52) | TK1LMNASMN1; SMN2TSHRTK2 | |
| Doxribtimine SCHEMBL10409131 | 0.94 | LMNA (0.47) | TK1LMNASMN1; SMN2TSHRTK2 | |
| Doxribtimine SCHEMBL3162205 | 0.92 | LMNA (0.45) | TK1LMNASMN1; SMN2TSHRTK2 | |
| Doxribtimine SCHEMBL341619 | 0.90 | LMNA (0.59) | TK1LMNASMN1; SMN2TSHRTK2 | |
| Doxribtimine SCHEMBL2195275 | 0.90 | TK1 (0.52) | TK1LMNASMN1; SMN2TSHRTK2 | |
| Doxribtimine SCHEMBL28850774 | 0.87 | LMNA (0.42) | TK1LMNASMN1; SMN2TSHRALB | |
| Doxribtimine SCHEMBL9465657 | 0.86 | TK1 (0.51) | TK1LMNASMN1; SMN2TSHRTK2 | |
| Doxribtimine SCHEMBL1164058 | 0.86 | TK1 (0.53) | TK1LMNASMN1; SMN2TSHRTK2 | |
| Doxribtimine SCHEMBL8366525 | 0.86 | TK1 (0.53) | TK1LMNASMN1; SMN2TSHRTK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7741081-B2 | Process for producing L-arginine, L-ornithine or L-citrulline | KYOWA HAKKO BIO CO., LTD. (JP) | 2010-06-22 | — | — | US | claimed |
| EP-1801206-B1 | METHOD FOR PRODUCING L-ARGININE, L-ORNITHINE OR L-CITRULLINE | KYOWA HAKKO BIO CO LTD (JP) | 2010-03-24 | — | — | EP | claimed |
| US-20090123980-A1 | PROCESS FOR PRODUCING L-ARGININE, L-ORNITHINE OR L-CITRULLINE | KYOWA HAKKO KOGYO CO., LTD. (JP) | 2009-05-14 | — | — | US | claimed |
| EP-1801206-A1 | METHOD FOR PRODUCING L-ARGININE, L-ORNITHINE OR L-CITRULLINE | KYOWA HAKKO KOGYO CO., LTD. (JP) | 2007-06-27 | — | — | EP | claimed |
| US-7741081-B2 | Process for producing L-arginine, L-ornithine or L-citrulline | KYOWA HAKKO BIO CO., LTD. (JP) | 2010-06-22 | — | — | US | disclosed |
| EP-1801206-B1 | METHOD FOR PRODUCING L-ARGININE, L-ORNITHINE OR L-CITRULLINE | KYOWA HAKKO BIO CO LTD (JP) | 2010-03-24 | — | — | EP | disclosed |
| US-20090123980-A1 | PROCESS FOR PRODUCING L-ARGININE, L-ORNITHINE OR L-CITRULLINE | KYOWA HAKKO KOGYO CO., LTD. (JP) | 2009-05-14 | — | — | US | disclosed |
| EP-1801206-A1 | METHOD FOR PRODUCING L-ARGININE, L-ORNITHINE OR L-CITRULLINE | KYOWA HAKKO KOGYO CO., LTD. (JP) | 2007-06-27 | — | — | EP | disclosed |