Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Doxribtimine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TK1 | P04183 | 4/20 | 0.51 |
| ▸ | LMNA | P02545 | 3/20 | 0.51 |
| ▸ | TSHR | P16473 | 2/20 | 0.51 |
| ▸ | ALB | P02768 | 1/20 | 0.51 |
| ▸ | PKM | P14618 | 1/20 | 0.51 |
| ▸ | BLM | P54132 | 1/20 | 0.51 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | TK2 | O00142 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Doxribtimine SCHEMBL8366525 | 0.98 | TK1 (0.53) | TK1LMNATSHRALBPKM | |
| Doxribtimine SCHEMBL1164058 | 0.98 | TK1 (0.53) | TK1LMNATSHRALBPKM | |
| Doxribtimine SCHEMBL28237206 | 0.97 | LMNA (0.51) | TK1LMNATSHRALBPKM | |
| Doxribtimine SCHEMBL5964873 | 0.95 | TK1 (0.50) | TK1LMNATSHRALBPKM | |
| Doxribtimine SCHEMBL10409131 | 0.94 | LMNA (0.47) | TK1LMNATSHRALBPKM | |
| Doxribtimine SCHEMBL341619 | 0.92 | LMNA (0.59) | TK1LMNATSHRALBPKM | |
| Deoxyadenosine SCHEMBL8028657 | 0.91 | DTYMK (0.58) | TK1LMNATSHRALBPKM | |
| Doxribtimine SCHEMBL27149426 | 0.91 | TK1 (0.46) | TK1LMNATSHRALBPKM | |
| Doxribtimine SCHEMBL3175760 | 0.90 | LMNA (0.46) | TK1LMNATSHRALBPKM | |
| Doxribtimine SCHEMBL9725040 | 0.90 | DTYMK (0.49) | TK1LMNATSHRALBPKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5252711-A | Monoclonal antibodies useful in deodorizing skin and antibody fragments thereof | THE GILLETTE COMPANY (US) | 1993-10-12 | — | — | US | disclosed |
| US-5069896-A | REACTION WITH CARRIER OR TRANSFER PROTEIN OF BACTERIAL CELL | THE GILLETTE COMPANY (US) | 1991-12-03 | — | — | US | disclosed |
| WO-1990015077-A1 | MONOCLONAL ANTIBODY SPECIFIC FOR BACTERIAL TRANSPORT PROTEINS, AND ANTIBODY-CONTAINING DEODORANT COMPOSITION | THE GILLETTE COMPANY (US) | 1990-12-13 | — | — | WO | disclosed |
| EP-0304329-A2 | Monoclonal antibodies and hybridomas and sensitized cells for HBs antigen assay | SHIONOGI SEIYAKU KABUSHIKI KAISHA trading under the name of SHIONOGI & CO. LTD. (JP) | 1989-02-22 | — | — | EP | disclosed |