Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP1 | P53582 | 5/20 | 0.58 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.53 |
| ▸ | ACHE | P22303 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | HTR2A | P28223 | 1/20 | 0.46 |
| ▸ | HTR2C | P28335 | 1/20 | 0.46 |
| ▸ | HTR2B | P41595 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | CYP24A1 | Q07973 | 4/20 | 0.45 |
| ▸ | CYP26A1 | O43174 | 2/20 | 0.45 |
| ▸ | CYP27A1 | Q02318 | 2/20 | 0.45 |
| ▸ | MIF | P14174 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23181421 | 0.81 | METAP1 (0.60) | METAP1CYP19A1ACHEALDH1A1KDM4E | |
| SCHEMBL316629 | 0.81 | ACHE (0.76) | METAP1CYP19A1ACHEALDH1A1KDM4E | |
| SCHEMBL31189156 | 0.80 | METAP1 (0.58) | METAP1CYP19A1ACHEALDH1A1KDM4E | |
| SCHEMBL4462617 | 0.80 | METAP1 (0.58) | METAP1CYP19A1ACHEALDH1A1KDM4E | |
| SCHEMBL13567459 | 0.78 | METAP1 (0.53) | METAP1CYP19A1ACHEALDH1A1KDM4E | |
| SCHEMBL7573550 | 0.78 | METAP1 (0.56) | METAP1CYP19A1ACHEALDH1A1HTR2A | |
| SCHEMBL14306761 | 0.78 | METAP1 (0.72) | METAP1CYP19A1ACHECYP24A1CYP26A1 | |
| SCHEMBL12043649 | 0.78 | METAP1 (0.56) | METAP1CYP19A1ACHEALDH1A1KDM4E | |
| SCHEMBL7590204 | 0.76 | METAP1 (0.55) | METAP1CYP19A1ACHEALDH1A1HTR2A | |
| SCHEMBL15617638 | 0.76 | METAP1 (0.70) | METAP1CYP19A1ACHEALDH1A1CYP24A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8093400-B2 | Compounds useful in therapy | PFIZER INC. (US) | 2012-01-10 | — | — | US | disclosed |
| US-20100317652-A1 | Compounds Useful In Therapy | PFIZER INC | 2010-12-16 | — | — | US | disclosed |
| US-7745630-B2 | Triazolyl piperidine arginine vasopressin receptor modulators | BRYANS JUSTIN STEPHEN | 2010-06-29 | — | — | US | disclosed |
| US-20050154024-A1 | Compounds useful in therapy | PFIZER INC | 2005-07-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050154024-A1 | Compounds useful in therapy | PTGER4, PTGER3, ALOX5 | METAP1 2794/4885CYP19A1 651/4885ACHE 4625/4885 |
| US-20100317652-A1 | Compounds Useful In Therapy | AVPR1A, AVPR1B, AVPR2 | METAP1 3256/4885CYP19A1 14/4885ACHE 1406/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.