SCHEMBL31663376

SCHEMBL31663376

Cc1c[nH]c2c(CO[Si](C)(C)C(C)(C)C)cccc12

nearest known ligand 0.36

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
REN P00797 2/20 0.36
BACE1 P56817 1/20 0.36
HTR2A P28223 1/20 0.35
NPSR1 Q6W5P4 2/20 0.35
MAPT P10636 2/20 0.35
SMN1; SMN2 Q16637 1/20 0.35
SOS2 Q07890 1/20 0.34
ALDH1A1 P00352 3/20 0.33
LMNA P02545 2/20 0.33
HTT P42858 1/20 0.33
ATM Q13315 1/20 0.33
MEN1 O00255 4/20 0.33
KMT2A Q03164 4/20 0.33
L3MBTL1 Q9Y468 1/20 0.33
GAA P10253 1/20 0.32
RAB9A P51151 1/20 0.32
NR4A2 P43354 1/20 0.31
TRIM24 O15164 1/20 0.31
TRIM33 Q9UPN9 1/20 0.31
GUCY1A1 Q02108 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14752417 0.78 BACE1 (0.36) BACE1
SCHEMBL31663308 0.76 BACE1 (0.32) BACE1
SCHEMBL31663371 0.76 BACE1 (0.32) BACE1
SCHEMBL7391015 0.75 BACE1 (0.44) BACE1ALDH1A1HTTATM
SCHEMBL15902401 0.74 AHR (0.38) RENBACE1HTR2A
SCHEMBL14738136 0.74 BACE1 (0.35) BACE1
SCHEMBL15902158 0.73 MEN1 (0.49) BACE1MAPTALDH1A1LMNAHTT
SCHEMBL31663167 0.73 BACE1 (0.33) BACE1
SCHEMBL13715228 0.72 ALDH1A1 (0.57) RENHTR2ANPSR1MAPTSMN1; SMN2
SCHEMBL5467148 0.72 BACE1 (0.39) BACE1MAPTALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2025149622-A1 WNK1 INHIBITORS DANIA THERAPEUTICS APS (DK) 2025-07-17 WO disclosed