Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | VCP | P55072 | 1/20 | 0.32 |
| ▸ | EGFR | P00533 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.30 |
| ▸ | DRD2 | P14416 | 1/20 | 0.30 |
| ▸ | DRD4 | P21917 | 1/20 | 0.30 |
| ▸ | DRD3 | P35462 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL3851767 | 0.99 | VCP (0.31) | VCPEGFRCYP2D6ALDH1A1HPGD | |
| SCHEMBL3841138 | 0.99 | VCP (0.32) | VCPEGFRCYP2D6ALDH1A1HPGD | |
| Hydrochloric Acid SCHEMBL1152587 | 0.98 | CYP2D6 (0.32) | VCPEGFRCYP2D6ALDH1A1HPGD | |
| Hydrochloric Acid SCHEMBL3860287 | 0.98 | CYP2D6 (0.32) | VCPEGFRCYP2D6ALDH1A1HPGD | |
| SCHEMBL3518957 | 0.98 | CYP2D6 (0.33) | VCPEGFRCYP2D6ALDH1A1HPGD | |
| SCHEMBL3840367 | 0.91 | CHRM2 (0.36) | VCPEGFRCYP2D6ALDH1A1HPGD | |
| SCHEMBL13646861 | 0.91 | CHRM2 (0.33) | VCPEGFR | |
| SCHEMBL3841457 | 0.90 | CHRM2 (0.35) | VCPALDH1A1HPGDKMT2ASLC22A2 | |
| SCHEMBL3835633 | 0.89 | CHRM2 (0.34) | VCPALDH1A1HPGDKMT2ASLC22A2 | |
| Hydrochloric Acid SCHEMBL3852369 | 0.89 | CNR1 (0.32) | EGFRKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7648536-B2 | Method of coloring keratinous fibers comprising application of at least one aminopyrazolopyridine oxidation base in the absence of chemical oxidizing agents | L'OREAL S.A. (FR) | 2010-01-19 | — | — | US | disclosed |
| US-20080289121-A1 | Method of coloring keratinous fibers comprising application of at least one aminopyrazolopyridine oxidation base in the absence of chemical oxidizing agents | L'ORE'AL S.A. (FR) | 2008-11-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080289121-A1 | Method of coloring keratinous fibers comprising application of at least one aminopyrazolopyridine oxidation base in the absence of chemical oxidizing agents | KRT18, CYBB, NOX5 | VCP 1912/4885EGFR 4510/4885CYP2D6 1020/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.