Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.33 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.32 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.32 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.32 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.32 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.32 |
| ▸ | VCP | P55072 | 1/20 | 0.32 |
| ▸ | EGFR | P00533 | 1/20 | 0.32 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.30 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.30 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.30 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.30 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.30 |
| ▸ | CHRNA10 | Q9GZZ6 | 1/20 | 0.30 |
| ▸ | CHRNA9 | Q9UGM1 | 1/20 | 0.30 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3841138 | 0.99 | VCP (0.32) | CYP2D6ALDH1A1HPGDKMT2ASLC22A2 | |
| Hydrochloric Acid SCHEMBL1152587 | 0.98 | CYP2D6 (0.32) | CYP2D6ALDH1A1HPGDKMT2ASLC22A2 | |
| Hydrochloric Acid SCHEMBL3860287 | 0.98 | CYP2D6 (0.32) | CYP2D6ALDH1A1HPGDKMT2ASLC22A2 | |
| Hydrochloric Acid SCHEMBL3166759 | 0.98 | VCP (0.32) | CYP2D6ALDH1A1HPGDKMT2ASLC22A2 | |
| Hydrochloric Acid SCHEMBL3851767 | 0.96 | VCP (0.31) | CYP2D6ALDH1A1HPGDKMT2ASLC22A2 | |
| SCHEMBL3840367 | 0.93 | CHRM2 (0.36) | CYP2D6ALDH1A1HPGDKMT2ASLC22A2 | |
| SCHEMBL3841457 | 0.92 | CHRM2 (0.35) | ALDH1A1HPGDKMT2ASLC22A2CHRM2 | |
| SCHEMBL3835633 | 0.91 | CHRM2 (0.34) | ALDH1A1HPGDKMT2ASLC22A2CHRM2 | |
| SCHEMBL13646861 | 0.91 | CHRM2 (0.33) | CHRM2CHRM4CHRM5CHRM1CHRM3 | |
| SCHEMBL3835579 | 0.88 | CNR1 (0.33) | KMT2AEGFRCHRNB2CHRNB4CHRNA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008149005-A2 | DYE COMPOSITION COMPRISING AN AMINOPYRAZOLOPYRIDINE OXIDATION BASE AND A SOURCE OF CARBONATE IONS | L'OREAL (FR) | 2008-12-11 | — | — | WO | claimed |
| EP-2246038-B1 | Azomethinic cationic pyrazolidine derivatives for dyeing keratin fiber | ORÉAL L (FR) | 2014-10-22 | — | — | EP | disclosed |
| US-7887601-B2 | 2-[(3-{[2-amino-5-methyl-4-oxocyclohexa-2,5-dien-1-ylidene]amino}pyrazolo[1,5-a]pyridin-2-yl)amino]-N,N,N-trimethylethanaminium chloride; leuco dyes; along with an oxididizer; hair dyes; intensity | L'OREAL S.A. (FR) | 2011-02-15 | — | — | US | disclosed |
| US-20100275390-A1 | COMPOUNDS OF AZOMETHINE TYPE COMPRISING A CATIONIC PYRAZOLOPYRIDINE UNIT, FOR DYEING KERATIN FIBRES | L'OREAL S.A. (FR) | 2010-11-04 | — | — | US | disclosed |
| EP-2246038-A1 | Azomethinic cationic pyrazolidine derivatives for dyeing keratin fiber | L'Oréal (FR) | 2010-11-03 | — | — | EP | disclosed |
| EP-1792903-B1 | Composition for the dyeing of keratin fibres comprising at least one cationic 3-amino-pyrazolopyridine derivative | OREAL (FR) | 2009-10-14 | — | — | EP | disclosed |
| EP-1792903-B1 | Composition for the dyeing of keratin fibres comprising at least one cationic 3-amino-pyrazolopyridine derivative | OREAL (FR) | 2009-10-14 | — | — | EP | disclosed |
| US-7578855-B2 | Composition for dyeing keratin fibers comprising at least one cationic 3-amino-pyrazolopyridine derivative, and methods of use thereof | L'ORéAL S.A. (FR) | 2009-08-25 | — | — | US | disclosed |
| WO-2008149005-A2 | DYE COMPOSITION COMPRISING AN AMINOPYRAZOLOPYRIDINE OXIDATION BASE AND A SOURCE OF CARBONATE IONS | L'OREAL (FR) | 2008-12-11 | — | — | WO | disclosed |
| WO-2008149005-A2 | DYE COMPOSITION COMPRISING AN AMINOPYRAZOLOPYRIDINE OXIDATION BASE AND A SOURCE OF CARBONATE IONS | L'OREAL (FR) | 2008-12-11 | — | — | WO | disclosed |
| WO-2008138845-A2 | COLOURING COMPOSITION COMPRISING AN AMINOPYRAZOLOPYRIDINE OXIDATION BASE AND EXHIBITING AN ACIDIC PH | L'OREAL (FR) | 2008-11-20 | — | — | WO | disclosed |
| US-20070136959-A1 | Composition for dyeing keratin fibers comprising at least one cationic 3-amino-pyrazolopyridine derivative, and methods of use thereof | L'OREAL S.A. (FR) | 2007-06-21 | — | — | US | disclosed |
| US-20070136959-A1 | Composition for dyeing keratin fibers comprising at least one cationic 3-amino-pyrazolopyridine derivative, and methods of use thereof | L'OREAL S.A. (FR) | 2007-06-21 | — | — | US | disclosed |
| EP-1792903-A1 | Composition for the dyeing of keratin fibres comprising at least one cationic 3-amino-pyrazolopyridine derivative | L'OREAL (FR) | 2007-06-06 | — | — | EP | disclosed |
| EP-1792903-A1 | Composition for the dyeing of keratin fibres comprising at least one cationic 3-amino-pyrazolopyridine derivative | L'OREAL (FR) | 2007-06-06 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070136959-A1 | Composition for dyeing keratin fibers comprising at least one cationic 3-amino-pyrazolopyridine derivative, and methods of use thereof | KRT18, COX5A, PNPO | CYP2D6 1275/4885ALDH1A1 264/4885HPGD 368/4885 |
| US-20100275390-A1 | COMPOUNDS OF AZOMETHINE TYPE COMPRISING A CATIONIC PYRAZOLOPYRIDINE UNIT, FOR DYEING KERATIN FIBRES | KRT18, TMPO, S100A4 | CYP2D6 714/4885ALDH1A1 1818/4885HPGD 1046/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.