Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 2/20 | 0.62 |
| ▸ | MAOA | P21397 | 1/20 | 0.62 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.59 |
| ▸ | RAB9A | P51151 | 6/20 | 0.56 |
| ▸ | NPC1 | O15118 | 4/20 | 0.56 |
| ▸ | MAPT | P10636 | 6/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | PKM | P14618 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | RXRA | P19793 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL377079 | 0.86 | MAOB (0.60) | MAOBNR4A2RAB9ANPC1MAPT | |
| SCHEMBL276803 | 0.86 | SMN1; SMN2 (0.61) | RAB9ANPC1MAPTSMN1; SMN2MEN1 | |
| SCHEMBL4709350 | 0.85 | HDAC3 (0.59) | MAOBNR4A2RAB9ANPC1MAPT | |
| SCHEMBL11087771 | 0.85 | MMP1 (0.55) | MAOBMAPTSMN1; SMN2MEN1KMT2A | |
| SCHEMBL11601734 | 0.83 | MAOB (0.68) | MAOBMAOANR4A2RAB9ANPC1 | |
| SCHEMBL21991755 | 0.83 | MAOB (0.60) | MAOBMAOANR4A2RAB9ANPC1 | |
| SCHEMBL4263364 | 0.82 | SMN1; SMN2 (0.56) | RAB9ANPC1MAPTSMN1; SMN2MEN1 | |
| SCHEMBL11830013 | 0.81 | NPC1 (0.62) | RAB9ANPC1MAPTSMN1; SMN2MEN1 | |
| SCHEMBL21992641 | 0.81 | MAOB (0.57) | MAOBMAOANR4A2RAB9ANPC1 | |
| SCHEMBL24805921 | 0.79 | L3MBTL1 (0.58) | MAOBMAOARAB9ANPC1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7645772-B2 | 4-(4-benzyloxy-3-chlorophenyl)-4-oxobutanoic acid; Methyl 4-(4-benzyloxy-2-methoxyphenyl)-4-oxobutanoate or derivatives for treatment of insulin resistance syndrome, diabetes, cachexia, hyperlipidemia, fatty liver disease, obesity, atherosclerosis or arteriosclerosis | WELLSTAT THERAPEUTICS CORPORATION (US) | 2010-01-12 | — | — | US | claimed |
| US-20060035970-A1 | Compounds for the treatment of metabolic disorders | WELLSTAT THERAPEUTICS CORPORATION | 2006-02-16 | — | — | US | claimed |
| EP-1556085-A2 | COMPOUNDS FOR THE TREATMENT OF METABOLIC DISORDERS | Wellstat Therapeutics Corporation (US) | 2005-07-27 | — | — | EP | claimed |
| WO-2004041165-A2 | COMPOUNDS FOR THE TREATMENT OF METABOLIC DISORDERS | WELLSTAT THERAPEUTICS CORPORATION (US) | 2004-05-21 | — | — | WO | claimed |
| US-7645772-B2 | 4-(4-benzyloxy-3-chlorophenyl)-4-oxobutanoic acid; Methyl 4-(4-benzyloxy-2-methoxyphenyl)-4-oxobutanoate or derivatives for treatment of insulin resistance syndrome, diabetes, cachexia, hyperlipidemia, fatty liver disease, obesity, atherosclerosis or arteriosclerosis | WELLSTAT THERAPEUTICS CORPORATION (US) | 2010-01-12 | — | — | US | disclosed |
| US-20060035970-A1 | Compounds for the treatment of metabolic disorders | WELLSTAT THERAPEUTICS CORPORATION | 2006-02-16 | — | — | US | disclosed |
| EP-1556085-A2 | COMPOUNDS FOR THE TREATMENT OF METABOLIC DISORDERS | Wellstat Therapeutics Corporation (US) | 2005-07-27 | — | — | EP | disclosed |
| WO-2004041165-A2 | COMPOUNDS FOR THE TREATMENT OF METABOLIC DISORDERS | WELLSTAT THERAPEUTICS CORPORATION (US) | 2004-05-21 | — | — | WO | disclosed |