Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIN1 | Q13526 | 2/20 | 0.72 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.56 |
| ▸ | PARP1 | P09874 | 1/20 | 0.53 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.52 |
| ▸ | GRK6 | P43250 | 1/20 | 0.49 |
| ▸ | AURKA | O14965 | 1/20 | 0.49 |
| ▸ | SMPD3 | Q9NY59 | 1/20 | 0.49 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | VDR | P11473 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.48 |
| ▸ | AHR | P35869 | 1/20 | 0.48 |
| ▸ | NR1I3 | Q14994 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | DHODH | Q02127 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20425475 | 0.92 | PIN1 (0.66) | PIN1SLC9A1PARP1HCRTR1AURKA | |
| Oxalic Acid SCHEMBL31679103 | 0.83 | SMPD3 (0.50) | PIN1PARP1SMPD3CYP1A2KDM4E | |
| Oxalic Acid SCHEMBL31679108 | 0.83 | PIN1 (0.63) | PIN1SLC9A1PARP1HCRTR1GRK6 | |
| SCHEMBL8963628 | 0.81 | PIN1 (0.81) | PIN1SLC9A1PARP1HCRTR1AURKA | |
| Oxalic Acid SCHEMBL31679101 | 0.81 | PIN1 (0.71) | PIN1SLC9A1PARP1KDM4EALDH1A1 | |
| SCHEMBL8963666 | 0.77 | PIN1 (0.73) | PIN1SLC9A1PARP1HCRTR1GRK6 | |
| SCHEMBL8964024 | 0.77 | PIN1 (0.62) | PIN1SLC9A1PARP1HCRTR1AURKA | |
| SCHEMBL3621960 | 0.74 | VDR (0.63) | PIN1VDRKDM4EALDH1A1NPC1 | |
| Oxalic Acid SCHEMBL31679093 | 0.74 | PIN1 (0.52) | PIN1PARP1GRK6AURKASMPD3 | |
| SCHEMBL25754934 | 0.74 | PIN1 (0.63) | PIN1SLC9A1PARP1GRK6AURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12403128-B2 | Compositions and methods for blocking sodium channels | Univerity of Virginia Patent Foundation (US) | 2025-09-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12403128-B2 | Compositions and methods for blocking sodium channels | SCN3A, SCN1B, SCN2B | PIN1 1981/4885SLC9A1 51/4885PARP1 4869/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.