Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR4 | O95977 | 6/20 | 0.51 |
| ▸ | MAPT | P10636 | 6/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.45 |
| ▸ | LMNA | P02545 | 4/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 5/20 | 0.43 |
| ▸ | NPC1 | O15118 | 3/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16938768 | 0.88 | NPC1 (0.46) | S1PR4MAPTALDH1A1LMNAMAPK1 | |
| SCHEMBL27625069 | 0.85 | S1PR4 (0.48) | S1PR4MAPTALDH1A1LMNAMAPK1 | |
| SCHEMBL23914959 | 0.84 | MAPT (0.51) | S1PR4MAPTALDH1A1LMNAMAPK1 | |
| SCHEMBL15716580 | 0.83 | S1PR4 (0.51) | S1PR4MAPTALDH1A1LMNAMAPK1 | |
| SCHEMBL6359199 | 0.82 | S1PR4 (0.45) | S1PR4MAPTALDH1A1LMNAMAPK1 | |
| SCHEMBL3165217 | 0.82 | MAPT (0.56) | S1PR4MAPTALDH1A1LMNAMAPK1 | |
| SCHEMBL9732941 | 0.81 | ALDH1A1 (0.46) | S1PR4MAPTALDH1A1LMNAMAPK1 | |
| SCHEMBL8297106 | 0.79 | L3MBTL1 (0.54) | S1PR4MAPTALDH1A1MAPK1POLB | |
| SCHEMBL6566114 | 0.78 | S1PR4 (0.41) | S1PR4MAPTALDH1A1LMNAL3MBTL1 | |
| SCHEMBL28696650 | 0.78 | S1PR4 (0.47) | S1PR4MAPTALDH1A1LMNAMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7645760-B2 | 1-(4-Benzyl-piperazin-1-yl)-3-phenyl-propenone derivatives | NOVARTIS AG. (CH) | 2010-01-12 | — | — | US | disclosed |
| US-7645760-B2 | 1-(4-Benzyl-piperazin-1-yl)-3-phenyl-propenone derivatives | NOVARTIS AG. (CH) | 2010-01-12 | — | — | US | disclosed |
| CN-101570517-A | 1- (4-benzyl-piperazin-1-yl) -3-phenyl-propenone derivatives | NOVARTIS AG (CH) | 2009-11-04 | — | — | CN | disclosed |
| CN-100554257-C | 1- (4-benzyl-piperazin-1-yl) -3-phenyl-propenone derivatives | NOVARTIS AG (CH) | 2009-10-28 | — | — | CN | disclosed |
| US-20060173004-A1 | 1-(4-Benzyl-piperazin-1-yl)-3-phenyl-propenone derivatives | NOVARTIS AG (CH) | 2006-08-03 | — | — | US | disclosed |
| CN-1708489-A | 1- (4-benzyl-piperazin-1-yl) -3-phenyl-propenone derivatives | NOVARTIS AG (CH) | 2005-12-14 | — | — | CN | disclosed |
| EP-1558594-A2 | 1-(4-BENZYL-PIPERAZIN-1-YL)-3-PHENYL-PROPENONE DERIVATIVES | Novartis AG (CH) | 2005-08-03 | — | — | EP | disclosed |
| WO-2004037796-A2 | 1-(4-BENZYL-PIPERAZIN-1-YL)-3-PHENYL-PROPENONE DERIVATIVES | NOVARTIS AG (CH) | 2004-05-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060173004-A1 | 1-(4-Benzyl-piperazin-1-yl)-3-phenyl-propenone derivatives | CCR1, CCR3, CCR4 | S1PR4 223/4885MAPT 2279/4885ALDH1A1 290/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.