Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F10 | P00742 | 9/20 | 0.45 |
| ▸ | SMYD3 | Q9H7B4 | 4/20 | 0.45 |
| ▸ | F2 | P00734 | 7/20 | 0.41 |
| ▸ | PRSS1 | P07477 | 7/20 | 0.41 |
| ▸ | ST14 | Q9Y5Y6 | 5/20 | 0.41 |
| ▸ | PRSS2 | P07478 | 4/20 | 0.41 |
| ▸ | PRSS3 | P35030 | 4/20 | 0.41 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.40 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.40 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.39 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.39 |
| ▸ | CCR9 | P51686 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28572149 | 0.93 | F10 (0.45) | F10SMYD3F2PRSS1ST14 | |
| SCHEMBL28572148 | 0.93 | F10 (0.45) | F10SMYD3F2PRSS1ST14 | |
| SCHEMBL31689657 | 0.88 | F2 (0.48) | F10SMYD3F2PRSS1ST14 | |
| SCHEMBL25016626 | 0.88 | F2 (0.48) | F10SMYD3F2PRSS1ST14 | |
| SCHEMBL28580154 | 0.87 | F10 (0.44) | F10SMYD3F2PRSS1ST14 | |
| SCHEMBL28580156 | 0.87 | F10 (0.44) | F10SMYD3F2PRSS1ST14 | |
| SCHEMBL28573728 | 0.87 | F2 (0.50) | F10SMYD3F2PRSS1ST14 | |
| SCHEMBL28573730 | 0.87 | F2 (0.50) | F10SMYD3F2PRSS1ST14 | |
| SCHEMBL21822277 | 0.87 | F10 (0.55) | F10SMYD3F2PRSS1ST14 | |
| SCHEMBL31689686 | 0.84 | SMYD3 (0.46) | F10SMYD3F2PRSS1ST14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12428415-B2 | Matriptase 2 inhibitors and uses thereof | DISC MEDICINE, INC. (US) | 2025-09-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12428415-B2 | Matriptase 2 inhibitors and uses thereof | MMP7, MATR3, SPINT2 | F10 1548/4885SMYD3 1773/4885F2 408/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.