Histatin 5

SCHEMBL31694496

C[C@H](NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)NCC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O

nearest known ligand 0.57

Full drug profile on Sugi Atlas →

Predicted protein targets (top 6)

	gene	UniProt	supporting neighbours	confidence
▸	GLP1R	P43220	16/20	0.57

▸	SCTR	P47872	1/20	0.57

▸	TFPI	P10646	1/20	0.57

▸	GCGR	P47871	1/20	0.55

▸	C5AR1	P21730	1/20	0.55

▸	MC4R	P32245	1/20	0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
Histatin 3 SCHEMBL31694493	0.94	TFPI (0.63)	GLP1RSCTRTFPIGCGRMC4R
SCHEMBL29658174	0.94	GLP1R (0.62)	GLP1RSCTRTFPIGCGR
SCHEMBL31694488	0.93	C5AR1 (0.58)	GLP1RSCTRTFPIGCGRC5AR1
SCHEMBL29622989	0.91	GLP1R (0.65)	GLP1RSCTRTFPIGCGR
SCHEMBL30538628	0.91	TFPI (0.68)	GLP1RSCTRTFPIGCGR
SCHEMBL31005069	0.90	TFPI (0.64)	GLP1RSCTRTFPIGCGR
Histatin 5 SCHEMBL29354282	0.89	VIPR1 (0.61)	GLP1RTFPI
SCHEMBL30903287	0.89	GLP1R (0.58)	GLP1R
SCHEMBL31032668	0.89	GLP1R (0.51)	GLP1RSCTRTFPIGCGRC5AR1
SCHEMBL31032683	0.89	GLP1R (0.51)	GLP1RSCTRTFPIGCGRC5AR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
US-RE50618-E1	Anionic-core composition for delivery of therapeutic agents, and methods of making and using the same	PHARMAIN CORPORATION (US)	2025-10-07	—	—	US	disclosed