Histatin 5

Histatin 5

SCHEMBL29354282

C[C@H](NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)NCC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O

nearest known ligand 0.61

Full drug profile on Sugi Atlas →

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
▸ VIPR1 P32241 5/20 0.61
▸ VIPR2 P41587 7/20 0.60
▸ CXCR4 P61073 1/20 0.60
▸ GLP1R P43220 4/20 0.59
▸ ECE1 P42892 1/20 0.59
▸ MUS81 Q96NY9 1/20 0.59
▸ NR3C1 P04150 3/20 0.58
▸ TFPI P10646 3/20 0.57
▸ OPRL1 P41146 1/20 0.57

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Histatin 3 SCHEMBL29445556 0.94 VIPR1 (0.69) VIPR1VIPR2GLP1RECE1MUS81
SCHEMBL29366375 0.93 VIPR2 (0.64) VIPR1VIPR2GLP1RECE1MUS81
SCHEMBL29581965 0.92 VIPR1 (0.55) VIPR1VIPR2CXCR4GLP1RECE1
Histatin 5 SCHEMBL31694496 0.89 GLP1R (0.57) GLP1RTFPI
SCHEMBL29679886 0.87 NPY5R (0.56) TFPI
SCHEMBL29405667 0.86 TFPI (0.66) TFPI
SCHEMBL29610203 0.85 VIPR1 (0.65) VIPR1VIPR2
SCHEMBL30900782 0.84 TFPI (0.65) TFPIOPRL1
SCHEMBL30900790 0.84 TFPI (0.65) TFPIOPRL1
Histatin 3 SCHEMBL31694493 0.84 TFPI (0.63) VIPR1VIPR2GLP1RTFPI

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 236 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260061092-A1 MINERALIZATION OF CELL-LADEN MATRICES UNIV OREGON HEALTH & SCIENCE (US) 2026-03-05 — — US claimed
EP-4677099-A2 HERBICIDE-RESISTANT GENES FOR MITOCHONDRIAL TRANSFORMATION Napigen, Inc. (US) 2026-01-14 — — EP claimed
EP-4626496-A1 BIOPROSTHETIC TISSUE AND PROSTHETIC ANTIMICROBIAL TREATMENT Edwards Lifesciences Corporation (US) 2025-10-08 — — EP claimed
US-20250296961-A1 ANTIMICROBIAL PEPTIDES FOR REMINERALIZATION OF TEETH AND PREVENTION OF DENTAL CARIES THE UNIVERSITY OF HONG KONG (CN) 2025-09-25 — — US claimed
US-20250275905-A1 ANTIBACTERIAL AND MINERALIZING COMPOSITIONS AND METHODS OF USE THEREOF THE UNIVERSITY OF HONG KONG (CN) 2025-09-04 — — US claimed
CN-119867265-A Tenderness agent for improving tenderness of stewed meat and use method thereof 河北农业大学 2025-04-25 — — CN claimed
US-20250027099-A1 PHOSPHITE DEHYDROGENASE AS A SELECTABLE MARKER FOR MITOCHONDRIAL TRANSFORMATION NAPIGEN, INC. 2025-01-23 — — US claimed
WO-2024187111-A2 HERBICIDE-RESISTANT GENES FOR MITOCHONDRIAL TRANSFORMATION NAPIGEN, INC. (US) 2024-09-12 — — WO claimed
EP-4380579-A1 MIRNA-BASED COMPOSITIONS AND METHODS OF USE THEREOF Leadermed Champion Limited (CN) 2024-06-12 — — EP claimed
WO-2024118297-A1 BIOPROSTHETIC TISSUE AND PROSTHETIC ANTIMICROBIAL TREATMENT EDWARDS LIFESCIENCES CORPORATION (US) 2024-06-06 — — WO claimed
EP-3129044-B1 PEPTIDOGLYCAN HYDROLASE FOR USE IN THE TREATMENT OF CHRONIC BACTERIAL INFECTIONS LYSANDO AG (LI) 2022-09-07 — — EP claimed
WO-2022174715-A1 ANTIBACTERIAL AND MINERALIZING COMPOSITIONS AND METHODS OF USE THEREOF THE UNIVERSITY OF HONG KONG (CN) 2022-08-25 — — WO claimed
WO-2022173893-A1 USE OF HISTIDINE RICH PEPTIDES AS A TRANSFECTION REAGENT FOR rAAV AND rBV PRODUCTION BIOMARIN PHARMACEUTICAL INC. (US) 2022-08-18 — — WO claimed
WO-2022174142-A1 COMPOSITIONS AND METHODS FOR USING COMBINATIONS OF ACTIN-BASED PEPTIDES TO MODULATE CELLULAR BIOACTIVITY AND CELLULAR SUSCEPTIBILITY TO INTRACELLULAR PATHOGENS Virongy L.L.C. (US) 2022-08-18 — — WO claimed
US-20220257593-A1 CARABACHOL-BROMONIDINE FORMULATION TO ENHANCE ANTI-PRESBYOPIA EFFECTS VISUS THERAPEUTICS, INC. 2022-08-18 — — US claimed
US-20220238042-A1 ENGINEERED BONE MARROW MODEL OREGON HEALTH & SCIENCE UNIVERSITY (US) 2022-07-28 — — US claimed
CN-114502155-A Carbachol-brimonidine formulations for enhanced anti-presbyopia 视觉治疗股份有限公司 2022-05-13 — — CN claimed
EP-3980005-A1 CARABACHOL-BROMONIDINE FORMULATION TO ENHANCE ANTI-PRESBYOPIA EFFECTS Visus Therapeutics, Inc. (US) 2022-04-13 — — EP claimed
EP-3966312-A1 ENGINEERED BONE MARROW MODEL Oregon Health & Science University (US) 2022-03-16 — — EP claimed
CN-114106937-A Contact lens care solution 东南大学 2022-03-01 — — CN claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260061092-A1 MINERALIZATION OF CELL-LADEN MATRICES COL2A1, FIBP, COL1A1 VIPR1 2873/4885VIPR2 2947/4885CXCR4 1264/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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