Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIA2 | P42262 | 1/20 | 0.38 |
| ▸ | IDO1 | P14902 | 2/20 | 0.37 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.37 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.36 |
| ▸ | MAOA | P21397 | 2/20 | 0.36 |
| ▸ | MAOB | P27338 | 2/20 | 0.36 |
| ▸ | AQP1 | P29972 | 1/20 | 0.35 |
| ▸ | FPR2 | P25090 | 1/20 | 0.34 |
| ▸ | PROKR1 | Q8TCW9 | 1/20 | 0.34 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.34 |
| ▸ | MIF | P14174 | 1/20 | 0.34 |
| ▸ | NAAA | Q02083 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.34 |
| ▸ | ESR1 | P03372 | 3/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3151260 | 0.92 | ALDH1A1 (0.38) | GRIA2IDO1LOXL2HSD11B1MAOA | |
| SCHEMBL13308398 | 0.91 | ALDH1A1 (0.40) | IDO1LOXL2HSD11B1MAOAMAOB | |
| SCHEMBL22728342 | 0.91 | ALDH1A1 (0.40) | IDO1LOXL2HSD11B1MAOAMAOB | |
| SCHEMBL2796832 | 0.88 | SLC6A2 (0.39) | GRIA2MAOAMAOBAQP1FPR2 | |
| Hydrochloric Acid SCHEMBL4635148 | 0.86 | SLC6A2 (0.38) | GRIA2MAOAMAOBFPR2PROKR1 | |
| SCHEMBL3353843 | 0.81 | CYP2D6 (0.42) | GRIA2MAOAMAOBAQP1FPR2 | |
| Hydrochloric Acid SCHEMBL22719271 | 0.80 | CYP2D6 (0.41) | GRIA2MAOAMAOBFPR2PROKR1 | |
| SCHEMBL23630297 | 0.80 | FPR2 (0.48) | IDO1HSD11B1MAOAMAOBFPR2 | |
| SCHEMBL6921 | 0.80 | BACE1 (0.47) | IDO1HSD11B1MAOAMAOBFPR2 | |
| SCHEMBL12027332 | 0.80 | FPR2 (0.40) | IDO1HSD11B1FPR2PROKR1TAAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1862457-B1 | Fluoropyrrolidines as dipeptidyl peptidase inhibitors | SMITHKLINE BEECHAM CORP (US) | 2010-01-20 | — | — | EP | disclosed |
| EP-1862457-A2 | Fluoropyrrolidines as dipeptidyl peptidase inhibitors | SmithKline Beecham Corporation (US) | 2007-12-05 | — | — | EP | disclosed |
| EP-1406873-B1 | FLUOROPYRROLIDINES AS DIPEPTIDYL PEPTIDASE INHIBITORS | SMITHKLINE BEECHAM CORP (US) | 2007-09-26 | — | — | EP | disclosed |
| US-7132443-B2 | Fluoropyrrolidines as dipeptidyl peptidase inhibitors | SMITHKLINEBEECHAM CORPORATION (US) | 2006-11-07 | — | — | US | disclosed |
| US-20040171848-A1 | Fluoropyrrolidines as dipeptidyl peptidase inhibitors | SMITHKLINE BEECHAM CORPORATION | 2004-09-02 | — | — | US | disclosed |
| EP-1406873-A2 | FLUOROPYRROLIDINES AS DIPEPTIDYL PEPTIDASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2004-04-14 | — | — | EP | disclosed |
| WO-2003002531-A2 | FLUOROPYRROLIDINES AS DIPEPTIDYL PEPTIDASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2003-01-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040171848-A1 | Fluoropyrrolidines as dipeptidyl peptidase inhibitors | DPP4, DPP3, DPP7 | GRIA2 3511/4885IDO1 2847/4885LOXL2 3104/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.