Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Lithium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B known ✓ | P49841 | 2/20 | 0.36 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.43 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.43 |
| ▸ | SYK | P43405 | 1/20 | 0.42 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.41 |
| ▸ | PIP5K1C | O60331 | 1/20 | 0.41 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.41 |
| ▸ | PI4KA | P42356 | 1/20 | 0.41 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.41 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.41 |
| ▸ | BRD4 | O60885 | 1/20 | 0.41 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.40 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.40 |
| ▸ | ACHE | P22303 | 2/20 | 0.38 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | IDH1 | O75874 | 1/20 | 0.37 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Lithium Ion SCHEMBL31705961 | 1.00 | MKNK1 (0.43) | MKNK1MKNK2SYKPIK3CDPIP5K1C | |
| SCHEMBL31705006 | 0.86 | KMO (0.47) | MKNK1MKNK2SYKPIK3CDPIP5K1C | |
| SCHEMBL31704964 | 0.83 | MKNK1 (0.45) | MKNK1MKNK2SYKPIK3CDPIP5K1C | |
| SCHEMBL31706115 | 0.83 | MKNK1 (0.45) | MKNK1MKNK2SYKPIK3CDPIP5K1C | |
| SCHEMBL21876279 | 0.76 | PIK3CD (0.52) | MKNK1MKNK2SYKPIK3CDPIP5K1C | |
| SCHEMBL29371998 | 0.76 | PIK3CD (0.52) | MKNK1MKNK2SYKPIK3CDPIP5K1C | |
| SCHEMBL28706416 | 0.72 | MAOA (0.43) | PIK3CDPIP5K1CPIK3CAPI4KAPIK3CG | |
| SCHEMBL29479615 | 0.72 | MAOA (0.43) | PIK3CDPIP5K1CPIK3CAPI4KAPIK3CG | |
| Lithium Ion SCHEMBL31704516 | 0.72 | KIT (0.45) | MKNK1MKNK2BRD4TTKGSK3B | |
| Lithium Ion SCHEMBL31705351 | 0.72 | KIT (0.45) | MKNK1MKNK2BRD4TTKGSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2025215110-A1 | NEW AMIDE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR USES AS SOS1 INHIBITORS | LES LABORATOIRES SERVIER (FR) | 2025-10-16 | — | — | WO | disclosed |