Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Lithium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B known ✓ | P49841 | 2/20 | 0.36 |
| ▸ | KIT | P10721 | 3/20 | 0.45 |
| ▸ | BRD4 | O60885 | 2/20 | 0.45 |
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.45 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.45 |
| ▸ | EIF4E | P06730 | 1/20 | 0.45 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.42 |
| ▸ | PIM1 | P11309 | 2/20 | 0.40 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.39 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.39 |
| ▸ | ABL1 | P00519 | 1/20 | 0.38 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.37 |
| ▸ | JAK2 | O60674 | 1/20 | 0.37 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.37 |
| ▸ | WNT1 | P04628 | 2/20 | 0.36 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.36 |
| ▸ | TTK | P33981 | 1/20 | 0.35 |
| ▸ | BMPR1A | P36894 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Lithium Ion SCHEMBL31705351 | 1.00 | KIT (0.45) | KITBRD4MKNK1MKNK2EIF4E | |
| SCHEMBL31704583 | 0.88 | KIT (0.46) | KITBRD4MKNK1MKNK2EIF4E | |
| SCHEMBL31706350 | 0.83 | MKNK1 (0.48) | KITBRD4MKNK1MKNK2EIF4E | |
| SCHEMBL31706532 | 0.83 | MKNK1 (0.48) | KITBRD4MKNK1MKNK2EIF4E | |
| Lithium Ion SCHEMBL31705265 | 0.72 | TBK1 (0.35) | — | |
| Lithium Ion SCHEMBL31704782 | 0.72 | TBK1 (0.35) | — | |
| Lithium Ion SCHEMBL31704813 | 0.72 | MKNK1 (0.43) | KITBRD4MKNK1MKNK2LRRK2 | |
| Lithium Ion SCHEMBL31705961 | 0.72 | MKNK1 (0.43) | KITBRD4MKNK1MKNK2LRRK2 | |
| Lithium Ion SCHEMBL31704679 | 0.71 | OPRM1 (0.34) | GSK3BDYRK1A | |
| Lithium Ion SCHEMBL31704957 | 0.71 | OPRM1 (0.34) | GSK3BDYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2025215110-A1 | NEW AMIDE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR USES AS SOS1 INHIBITORS | LES LABORATOIRES SERVIER (FR) | 2025-10-16 | — | — | WO | disclosed |