Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Lithium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 1/20 | 0.35 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.35 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.35 |
| ▸ | SPR | P35270 | 2/20 | 0.34 |
| ▸ | FAAH | O00519 | 5/20 | 0.34 |
| ▸ | SMYD3 | Q9H7B4 | 3/20 | 0.34 |
| ▸ | DPP4 | P27487 | 1/20 | 0.33 |
| ▸ | PPARG | P37231 | 1/20 | 0.33 |
| ▸ | TNKS | O95271 | 1/20 | 0.33 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | NAMPT | P43490 | 2/20 | 0.33 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31705599 | 0.84 | HRH3 (0.39) | SPRFAAHSMYD3PPARGTSHR | |
| SCHEMBL31705694 | 0.84 | HRH3 (0.39) | SPRFAAHSMYD3PPARGTSHR | |
| Lithium Ion SCHEMBL31704965 | 0.79 | MAPT (0.34) | TNKSTNKS2NAMPT | |
| Lithium Ion SCHEMBL31705008 | 0.79 | MAPT (0.34) | TNKSTNKS2NAMPT | |
| Lithium Ion SCHEMBL31706130 | 0.78 | PIM1 (0.35) | PIM1PIM3PIM2 | |
| Lithium Ion SCHEMBL31706742 | 0.78 | PIM1 (0.35) | PIM1PIM3PIM2 | |
| Lithium Ion SCHEMBL31706463 | 0.77 | DGAT2 (0.35) | SMYD3TNKSTNKS2NAMPT | |
| Lithium Ion SCHEMBL31705486 | 0.77 | NAMPT (0.37) | DPP4TNKSTNKS2TSHRNAMPT | |
| Lithium Ion SCHEMBL31706602 | 0.77 | NAMPT (0.37) | DPP4TNKSTNKS2TSHRNAMPT | |
| Lithium Ion SCHEMBL31705638 | 0.77 | DGAT2 (0.35) | SMYD3TNKSTNKS2NAMPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2025215110-A1 | NEW AMIDE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR USES AS SOS1 INHIBITORS | LES LABORATOIRES SERVIER (FR) | 2025-10-16 | — | — | WO | disclosed |