Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Lithium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT2 | Q96PD7 | 3/20 | 0.35 |
| ▸ | NAMPT | P43490 | 7/20 | 0.35 |
| ▸ | TNKS | O95271 | 1/20 | 0.34 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | POLB | P06746 | 2/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.32 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.32 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.32 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.32 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.31 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.31 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.31 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.31 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.31 |
| ▸ | HTR2B | P41595 | 1/20 | 0.31 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | BLM | P54132 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Lithium Ion SCHEMBL31705638 | 1.00 | DGAT2 (0.35) | DGAT2NAMPTTNKSTNKS2ALDH1A1 | |
| SCHEMBL31706867 | 0.88 | DGAT2 (0.36) | DGAT2NAMPTTNKSTNKS2ALDH1A1 | |
| SCHEMBL31705105 | 0.83 | CHRM4 (0.37) | DGAT2NAMPTALDH1A1POLBSMN1; SMN2 | |
| Lithium Ion SCHEMBL31704471 | 0.79 | CNR2 (0.40) | DGAT2ALDH1A1POLBHPGDBLM | |
| Lithium Ion SCHEMBL31705153 | 0.77 | PIM1 (0.35) | NAMPTTNKSTNKS2SMYD3 | |
| Lithium Ion SCHEMBL31704965 | 0.77 | MAPT (0.34) | DGAT2NAMPTTNKSTNKS2ALDH1A1 | |
| Lithium Ion SCHEMBL31705008 | 0.77 | MAPT (0.34) | DGAT2NAMPTTNKSTNKS2ALDH1A1 | |
| Lithium Ion SCHEMBL31706481 | 0.77 | TDP1 (0.37) | NAMPTALDH1A1POLBSMN1; SMN2CHRM1 | |
| Potassium Ion SCHEMBL31705065 | 0.77 | CKS1B (0.39) | ALDH1A1SMN1; SMN2HPGDHSD17B10 | |
| Lithium Ion SCHEMBL31705497 | 0.76 | NAMPT (0.39) | NAMPTTNKSTNKS2TLR9TLR8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2025215110-A1 | NEW AMIDE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR USES AS SOS1 INHIBITORS | LES LABORATOIRES SERVIER (FR) | 2025-10-16 | — | — | WO | disclosed |