Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Lithium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TARDBP | Q13148 | 1/20 | 0.36 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.33 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.33 |
| ▸ | FFAR2 | O15552 | 3/20 | 0.32 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.32 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.32 |
| ▸ | LRRK2 | Q5S007 | 3/20 | 0.32 |
| ▸ | VNN1 | O95497 | 1/20 | 0.31 |
| ▸ | OGA | O60502 | 1/20 | 0.31 |
| ▸ | KCNJ1 | P48048 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Lithium Ion SCHEMBL31705742 | 1.00 | TARDBP (0.36) | TARDBPCYP11B1CYP11B2FFAR2CHRM2 | |
| SCHEMBL31706406 | 0.88 | RBP4 (0.37) | TARDBPFFAR2CHRM2CHRM3LRRK2 | |
| SCHEMBL31705022 | 0.84 | CRBN (0.39) | TARDBPFFAR2CHRM2CHRM3LRRK2 | |
| Lithium Ion SCHEMBL31706366 | 0.81 | ALDH1A1 (0.43) | — | |
| Lithium Ion SCHEMBL31705448 | 0.81 | ALDH1A1 (0.43) | — | |
| Lithium Ion SCHEMBL31705320 | 0.69 | CASP1 (0.33) | — | |
| Lithium Ion SCHEMBL31706297 | 0.69 | CASP1 (0.33) | — | |
| Potassium Ion SCHEMBL31705065 | 0.68 | CKS1B (0.39) | — | |
| SCHEMBL25339027 | 0.65 | SMPD3 (0.44) | — | |
| SCHEMBL31560447 | 0.65 | KDM4E (0.47) | TARDBP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2025215110-A1 | NEW AMIDE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR USES AS SOS1 INHIBITORS | LES LABORATOIRES SERVIER (FR) | 2025-10-16 | — | — | WO | disclosed |