Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Lithium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 5/20 | 0.37 |
| ▸ | PIK3CA | P42336 | 4/20 | 0.37 |
| ▸ | FLT3 | P36888 | 1/20 | 0.36 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.33 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.33 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.33 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.33 |
| ▸ | KMO | O15229 | 3/20 | 0.33 |
| ▸ | JAK3 | P52333 | 1/20 | 0.32 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.32 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.32 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.32 |
| ▸ | ABL1 | P00519 | 1/20 | 0.31 |
| ▸ | GCK | P35557 | 1/20 | 0.31 |
| ▸ | CSF1R | P07333 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Lithium Ion SCHEMBL31705522 | 1.00 | PIK3CD (0.37) | PIK3CDPIK3CAFLT3CYP11B2PIK3CB | |
| SCHEMBL31706000 | 0.85 | KMO (0.47) | KMO | |
| SCHEMBL31705158 | 0.81 | GCK (0.38) | PIK3CDPIK3CAFLT3PIK3CBPIK3CG | |
| Lithium Ion SCHEMBL31704606 | 0.79 | PIK3CD (0.44) | PIK3CDPIK3CACYP11B2PIK3CBPIK3CG | |
| Lithium Ion SCHEMBL31705859 | 0.79 | PIK3CD (0.44) | PIK3CDPIK3CACYP11B2PIK3CBPIK3CG | |
| Lithium Ion SCHEMBL31706664 | 0.72 | PIK3CA (0.46) | PIK3CDPIK3CADYRK1AIKBKETBK1 | |
| SCHEMBL23012525 | 0.72 | ASIC3 (0.41) | PIK3CDPIK3CAFLT3PIK3CBPIK3CG | |
| Lithium Ion SCHEMBL31704792 | 0.70 | PIK3CA (0.50) | PIK3CDPIK3CADYRK1AKMOIKBKE | |
| Lithium Ion SCHEMBL31706112 | 0.70 | PLA2G10 (0.34) | PIK3CDPIK3CAIRAK4 | |
| Lithium Ion SCHEMBL31706638 | 0.70 | PIK3CA (0.50) | PIK3CDPIK3CADYRK1AKMOIKBKE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2025215110-A1 | NEW AMIDE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR USES AS SOS1 INHIBITORS | LES LABORATOIRES SERVIER (FR) | 2025-10-16 | — | — | WO | disclosed |