Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Lithium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK1 | P23458 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | NAMPT | P43490 | 10/20 | 0.42 |
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
| ▸ | TYK2 | P29597 | 1/20 | 0.40 |
| ▸ | KIT | P10721 | 3/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Lithium Ion SCHEMBL31704634 | 1.00 | JAK1 (0.44) | JAK1ALDH1A1GAAALOX15TSHR | |
| Lithium Ion SCHEMBL31704850 | 0.90 | NAMPT (0.42) | JAK1ALDH1A1GAAALOX15TSHR | |
| Lithium Ion SCHEMBL31705374 | 0.90 | NAMPT (0.42) | JAK1ALDH1A1GAAALOX15TSHR | |
| SCHEMBL31705506 | 0.88 | JAK1 (0.45) | JAK1ALDH1A1GAAALOX15TSHR | |
| Lithium Ion SCHEMBL31706510 | 0.85 | QDPR (0.51) | ALDH1A1GAAALOX15TSHRNAMPT | |
| Lithium Ion SCHEMBL31705789 | 0.85 | QDPR (0.51) | ALDH1A1GAAALOX15TSHRNAMPT | |
| SCHEMBL31704700 | 0.84 | NAMPT (0.48) | JAK1ALDH1A1GAAALOX15TSHR | |
| Lithium Ion SCHEMBL31705016 | 0.83 | ALDH1A1 (0.51) | JAK1ALDH1A1GAAALOX15TSHR | |
| Lithium Ion SCHEMBL31706014 | 0.83 | ALDH1A1 (0.51) | JAK1ALDH1A1GAAALOX15TSHR | |
| Lithium Ion SCHEMBL31705308 | 0.78 | ALDH1A1 (0.46) | JAK1ALDH1A1GAAALOX15TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2025215110-A1 | NEW AMIDE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR USES AS SOS1 INHIBITORS | LES LABORATOIRES SERVIER (FR) | 2025-10-16 | — | — | WO | disclosed |