Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | ADORA3 | P0DMS8 | 4/20 | 0.48 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | ABL1 | P00519 | 2/20 | 0.44 |
| ▸ | BCR | P11274 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | LTA4H | P09960 | 1/20 | 0.44 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.44 |
| ▸ | SCD | O00767 | 1/20 | 0.44 |
| ▸ | PTGDR | Q13258 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3258747 | 0.89 | ADORA3 (0.57) | MAPTMEN1KMT2AADORA3NPC1 | |
| SCHEMBL3163156 | 0.88 | RAB9A (0.48) | MAPTMEN1KMT2AADORA3NPC1 | |
| SCHEMBL3166181 | 0.88 | TRPV1 (0.54) | MEN1KMT2AADORA3NPC1RAB9A | |
| SCHEMBL3172697 | 0.87 | NPC1 (0.47) | MAPTMEN1KMT2AADORA3NPC1 | |
| SCHEMBL3175775 | 0.87 | ADORA3 (0.48) | MAPTMEN1KMT2AADORA3NPC1 | |
| SCHEMBL3176265 | 0.87 | MEN1 (0.50) | MEN1KMT2AADORA3SMN1; SMN2L3MBTL1 | |
| SCHEMBL3177044 | 0.87 | KMT2A (0.53) | MAPTMEN1KMT2ANPC1RAB9A | |
| SCHEMBL3176983 | 0.87 | ADORA3 (0.57) | MAPTMEN1KMT2AADORA3NPC1 | |
| SCHEMBL3163297 | 0.86 | NPC1 (0.55) | MAPTMEN1KMT2AADORA3NPC1 | |
| SCHEMBL3170553 | 0.86 | TP53 (0.53) | MAPTMEN1KMT2AADORA3NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1465631-B1 | PYRIMIDINE A2B SELECTIVE ANTAGONIST COMPOUNDS, THEIR SYNTHESIS AND USE | OSI PHARM INC (US) | 2010-02-24 | — | — | EP | disclosed |