Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | MC4R | P32245 | 1/20 | 0.39 |
| ▸ | DPP4 | P27487 | 1/20 | 0.38 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.37 |
| ▸ | DRD2 | P14416 | 2/20 | 0.37 |
| ▸ | KRAS | P01116 | 1/20 | 0.37 |
| ▸ | TACR3 | P29371 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | PHGDH | O43175 | 1/20 | 0.36 |
| ▸ | NAMPT | P43490 | 1/20 | 0.36 |
| ▸ | MTOR | P42345 | 1/20 | 0.36 |
| ▸ | RPTOR | Q8N122 | 1/20 | 0.36 |
| ▸ | MLST8 | Q9BVC4 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3157437 | 0.90 | GRM5 (0.41) | GRM5ALDH1A1HPGDALOX15HTT | |
| SCHEMBL3170303 | 0.86 | SMN1; SMN2 (0.45) | ALDH1A1ALOX15SMN1; SMN2TSHR | |
| SCHEMBL3171977 | 0.84 | ALDH1A1 (0.45) | ALDH1A1HTTSMN1; SMN2ADRB3TSHR | |
| SCHEMBL3163995 | 0.80 | KDM4E (0.50) | ALDH1A1HPGDHTTSMN1; SMN2HSD17B10 | |
| SCHEMBL4797943 | 0.80 | ALDH1A1 (0.46) | ALDH1A1HPGDALOX15HTTSMN1; SMN2 | |
| SCHEMBL3163269 | 0.80 | DRD2 (0.40) | GRM5ALDH1A1SMN1; SMN2DRD2DRD4 | |
| SCHEMBL3175358 | 0.79 | CHRM1 (0.40) | SMN1; SMN2 | |
| SCHEMBL3170296 | 0.77 | SMN1; SMN2 (0.43) | ALDH1A1ALOX15SMN1; SMN2TSHR | |
| SCHEMBL3167885 | 0.77 | HTT (0.38) | HTTADRB3TSHR | |
| SCHEMBL3156925 | 0.77 | MAPT (0.53) | ALDH1A1HPGDSMN1; SMN2HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1716128-B1 | SUBSTITUTED 4,5,6,7-TETRAHYDRO-BENZOTHIAZOL-2-YLAMINE COMPOUNDS | GRUENENTHAL GMBH (DE) | 2010-03-31 | — | — | EP | claimed |