Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.53 |
| ▸ | PKM | P14618 | 2/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.52 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | EGFR | P00533 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.43 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.41 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | ESR1 | P03372 | 2/20 | 0.41 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3170956 | 1.00 | LMNA (0.53) | LMNAPKMHTTALDH1A1SMN1; SMN2 | |
| SCHEMBL3163351 | 0.91 | SMN1; SMN2 (0.51) | LMNAPKMHTTALDH1A1SMN1; SMN2 | |
| SCHEMBL3163340 | 0.91 | SMN1; SMN2 (0.51) | LMNAPKMHTTALDH1A1SMN1; SMN2 | |
| SCHEMBL3171072 | 0.91 | PIM2 (0.54) | ALDH1A1SMN1; SMN2PIM2NPC1RAB9A | |
| SCHEMBL3171042 | 0.91 | PIM2 (0.54) | ALDH1A1SMN1; SMN2PIM2NPC1RAB9A | |
| SCHEMBL3161484 | 0.88 | LMNA (0.53) | LMNAPKMHTTALDH1A1SMN1; SMN2 | |
| SCHEMBL3161481 | 0.88 | LMNA (0.53) | LMNAPKMHTTALDH1A1SMN1; SMN2 | |
| SCHEMBL3170642 | 0.86 | KMT2A (0.49) | LMNAALDH1A1SMN1; SMN2PIM2NPC1 | |
| SCHEMBL3170630 | 0.86 | KMT2A (0.49) | LMNAALDH1A1SMN1; SMN2PIM2NPC1 | |
| SCHEMBL3160896 | 0.84 | PIM2 (0.49) | LMNAALDH1A1PIM2MAPTADORA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1465631-B1 | PYRIMIDINE A2B SELECTIVE ANTAGONIST COMPOUNDS, THEIR SYNTHESIS AND USE | OSI PHARM INC (US) | 2010-02-24 | — | — | EP | disclosed |