SCHEMBL3171502

SCHEMBL3171502

COc1ccc(COC(=O)C#CCNCC(=O)OCC(C)C)cc1

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 5/20 0.43
KMT2A Q03164 3/20 0.43
CACNA1B Q00975 1/20 0.41
GAA P10253 3/20 0.40
ATM Q13315 1/20 0.39
HTT P42858 2/20 0.38
CTSL P07711 1/20 0.37
CTSS P25774 1/20 0.37
CTSK P43235 1/20 0.37
P2RX4 Q99571 1/20 0.37
MEN1 O00255 1/20 0.36
MAPT P10636 1/20 0.36
MIF P14174 1/20 0.36
CA1 P00915 1/20 0.36
CA2 P00918 1/20 0.36
ACHE P22303 1/20 0.36
CYP1A2 P05177 1/20 0.36
CYP3A4 P08684 1/20 0.36
CYP2D6 P10635 1/20 0.36
CYP2C19 P33261 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3170543 0.88 ALDH1A1 (0.46) ALDH1A1KMT2AGAAATMHTT
SCHEMBL3170525 0.87 ALDH1A1 (0.41) ALDH1A1KMT2AGAAATMHTT
SCHEMBL3175029 0.87 ALDH1A1 (0.40) ALDH1A1ATMCTSLCTSSCTSK
SCHEMBL3177192 0.87 KMT2A (0.46) ALDH1A1KMT2AGAAATMHTT
SCHEMBL3170802 0.85 ALDH1A1 (0.44) ALDH1A1KMT2AGAAATMHTT
SCHEMBL3174637 0.84 ALDH1A1 (0.39) ALDH1A1KMT2AGAAATMHTT
SCHEMBL3182451 0.84 ALDH1A1 (0.43) ALDH1A1KMT2AGAAHTTMIF
SCHEMBL3175114 0.84 ALDH1A1 (0.46) ALDH1A1GAAHTTMAPT
SCHEMBL3161693 0.83 FFAR1 (0.47) ALDH1A1KMT2AGAAATMHTT
SCHEMBL3175077 0.83 ALDH1A1 (0.44) ALDH1A1KMT2ACACNA1BGAAATM

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7645607-B2 Method for producing optically active N-protected-propargylglycine SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2010-01-12 US disclosed
EP-1705252-B1 Method for producing optically active N-protected-propargylglycine SUMITOMO CHEMICAL CO (JP) 2008-07-16 EP disclosed
US-20060216806-A1 Method for producing optically active N-protected-propargylglycine SUMITOMO CHEMICAL COMPANY, LIMITED 2006-09-28 US disclosed
EP-1705252-A1 Method for producing optically active N-protected-propargylglycine Sumitomo Chemical Company, Limited (JP) 2006-09-27 EP disclosed