SCHEMBL31716040

SCHEMBL31716040

COc1cc2nc(Cc3ccc(-c4cc(F)cc(CNC(=O)OC(C)(C)C)c4)nc3)[nH]c(=O)c2cc1OC

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ LMNA P02545 4/20 0.41
▸ KDM4E B2RXH2 3/20 0.41
▸ GAA P10253 1/20 0.41
▸ GRM2 Q14416 1/20 0.41
▸ DYRK1A Q13627 1/20 0.40
▸ TDP1 Q9NUW8 2/20 0.39
▸ MAPK1 P28482 2/20 0.38
▸ ALDH1A1 P00352 4/20 0.38
▸ PTGES O14684 1/20 0.38
▸ USP2 O75604 1/20 0.38
▸ ALOX15 P16050 1/20 0.38
▸ MAPT P10636 1/20 0.37
▸ DNMT3A Q9Y6K1 1/20 0.36
▸ RET P07949 1/20 0.36
▸ MET P08581 1/20 0.35
▸ MEN1 O00255 2/20 0.35
▸ KMT2A Q03164 2/20 0.35
▸ HPGD P15428 1/20 0.35
▸ POLB P06746 1/20 0.35
▸ TSHR P16473 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL31716568 0.83 LMNA (0.45) LMNAKDM4EGAATDP1MAPK1
SCHEMBL31717042 0.80 LMNA (0.43) LMNAKDM4EGAATDP1MAPK1
SCHEMBL31716955 0.80 LMNA (0.43) LMNAKDM4EGAATDP1MAPK1
SCHEMBL31716946 0.80 LMNA (0.44) LMNAKDM4EGAATDP1MAPK1
SCHEMBL31715978 0.80 LMNA (0.48) LMNAKDM4EGAATDP1MAPK1
SCHEMBL31716050 0.79 LMNA (0.43) LMNAKDM4EGAATDP1MAPK1
Hydrochloric Acid SCHEMBL31716036 0.79 LMNA (0.41) LMNA
SCHEMBL31715994 0.79 KDM4E (0.46) LMNAKDM4EGAATDP1MAPK1
SCHEMBL31715980 0.78 LMNA (0.42) LMNAKDM4EGAATDP1MAPK1
SCHEMBL31716882 0.78 MAPK1 (0.46) LMNAKDM4EGAATDP1MAPK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2025227032-A1 METHODS FOR DEGRADATION OF CYCLIN K AND INHIBITION OF CYCLIN DEPENDENT KINASES REMIX THERAPEUTICS INC. (US) 2025-10-30 — — WO disclosed
Send feedback