SCHEMBL31716050

SCHEMBL31716050

COc1cc2nc(Cc3ccc(-c4cc(F)cc(F)c4)nc3)[nH]c(=O)c2cc1Br

nearest known ligand 0.43

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
▸ LMNA P02545 4/20 0.43
▸ RNASEH1 O60930 1/20 0.41
▸ MAPK1 P28482 2/20 0.40
▸ KDM4E B2RXH2 4/20 0.40
▸ GAA P10253 1/20 0.40
▸ ROCK2 O75116 1/20 0.39
▸ TDP1 Q9NUW8 1/20 0.39
▸ CASP1 P29466 1/20 0.38
▸ HBB P68871 1/20 0.38
▸ ALDH1A1 P00352 2/20 0.38
▸ USP2 O75604 1/20 0.38
▸ ALOX15 P16050 1/20 0.38
▸ MET P08581 2/20 0.38
▸ THRB P10828 1/20 0.36
▸ MAPT P10636 1/20 0.36
▸ TRPV1 Q8NER1 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31716946 0.97 LMNA (0.44) LMNARNASEH1MAPK1KDM4EGAA
SCHEMBL31716955 0.89 LMNA (0.43) LMNAMAPK1KDM4EGAAROCK2
SCHEMBL31716933 0.89 LMNA (0.43) LMNARNASEH1MAPK1KDM4EGAA
SCHEMBL31717042 0.87 LMNA (0.43) LMNARNASEH1MAPK1KDM4EGAA
SCHEMBL31716882 0.86 MAPK1 (0.46) LMNAMAPK1KDM4EGAAROCK2
SCHEMBL31716038 0.86 KDM4E (0.37) LMNARNASEH1MAPK1KDM4EGAA
SCHEMBL31715994 0.85 KDM4E (0.46) LMNAMAPK1KDM4EGAAROCK2
Hydrochloric Acid SCHEMBL31716568 0.85 LMNA (0.45) LMNAMAPK1KDM4EGAAROCK2
SCHEMBL31716260 0.85 PDE5A (0.36) LMNARNASEH1KDM4EGAAROCK2
SCHEMBL31715976 0.84 KDM4E (0.49) LMNAKDM4EROCK2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2025227032-A1 METHODS FOR DEGRADATION OF CYCLIN K AND INHIBITION OF CYCLIN DEPENDENT KINASES REMIX THERAPEUTICS INC. (US) 2025-10-30 — — WO disclosed
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