Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.56 |
| ▸ | POLB | P06746 | 2/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.51 |
| ▸ | NR1I3 | Q14994 | 2/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | VDR | P11473 | 1/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.51 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.51 |
| ▸ | AHR | P35869 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.48 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 3/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | PRNP | P04156 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29487316 | 1.00 | MAPT (0.56) | MAPTPOLBCYP1A2NR1I3CYP3A4 | |
| Hydrochloric Acid SCHEMBL8442906 | 0.98 | MAPT (0.54) | MAPTPOLBCYP1A2NR1I3CYP3A4 | |
| SCHEMBL14688000 | 0.88 | MAPT (0.47) | MAPTPOLBCYP1A2NR1I3CYP3A4 | |
| SCHEMBL6042690 | 0.80 | LMNA (0.68) | MAPTPOLBCYP1A2NR1I3CYP3A4 | |
| SCHEMBL7048658 | 0.79 | CYP1A2 (0.58) | MAPTPOLBCYP1A2NR1I3CYP3A4 | |
| SCHEMBL1995850 | 0.78 | NR1I3 (0.56) | MAPTPOLBCYP1A2NR1I3CYP3A4 | |
| SCHEMBL148103 | 0.78 | DCPS (0.57) | MAPTPOLBCYP1A2MAPK1ALDH1A1 | |
| SCHEMBL30380181 | 0.78 | POLB (0.52) | MAPTPOLBALDH1A1HPGDKDM4E | |
| SCHEMBL1083965 | 0.77 | MAPT (0.81) | MAPTPOLBCYP1A2NR1I3CYP3A4 | |
| SCHEMBL31529342 | 0.77 | MAPT (0.81) | MAPTPOLBCYP1A2NR1I3CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 708 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109553612-A | A kind of Pyrazolopyrimidine derivative and preparation method thereof and the purposes in medicine preparation | 广西梧州制药（集团）股份有限公司 | 2019-04-02 | — | — | CN | claimed |
| CN-108276393-A | A kind of synthetic method of Doxazosin impurity | 合肥华方医药科技有限公司 | 2018-07-13 | — | — | CN | claimed |
| CN-106083740-B | The 4- anilinoquinazoline derivatives and preparation method of a kind of triazole containing 1,2,3- | 江苏开放大学 | 2018-05-15 | — | — | CN | claimed |
| CN-107245072-A | A kind of preparation method of the triazole compound of Tarceva 1,2,3 | 河南师范大学 | 2017-10-13 | — | — | CN | claimed |
| CN-106946857-A | 3-triazole compounds of Tarceva 1,2,3 with antitumor activity and its preparation method and application | 河南师范大学 | 2017-07-14 | — | — | CN | claimed |
| CN-106632271-A | Erlotinib derivative with antitumor activity, and preparation method and application thereof | 河南师范大学 | 2017-05-10 | — | — | CN | claimed |
| US-9441199-B2 | Cells exhibiting neuronal progenitor cell characteristics and methods of making them | SANBIO, INC. (US) | 2016-09-13 | — | — | US | claimed |
| CN-102471274-B | For preparation method and the material of the substituted pyridine compounds of N- | 霍夫曼-拉罗奇有限公司 | 2016-08-03 | — | — | CN | claimed |
| US-20150267169-A1 | CELLS EXHIBITING NEURONAL PROGENITOR CELL CHARACTERISTICS AND METHODS OF MAKING THEM | SANBIO, INC. (US) | 2015-09-24 | — | — | US | claimed |
| CN-103509005-B | Quinazoline compound as well as preparation method and application thereof | SUZHOU HAITE BIAO BIOLOG TECHNOLOGY CO LTD | 2015-04-08 | — | — | CN | claimed |
| CN-1187129-A | Protein tyrosine kinase aryl and heteroaryl quinazoline compounds having selective inhibition of HER-2 autophosphorylation properties | RHONE POULENC RORER PHARMA (US) | 1998-07-08 | — | — | CN | claimed |
| WO-1998010767-A2 | USE OF QUINAZOLINE DERIVATIVES FOR THE MANUFACTURE OF A MEDICAMENT IN THE TREATMENT OF HYPERPROLIFERATIVE SKIN DISORDERS | SUGEN, INC. (US) | 1998-03-19 | — | — | WO | claimed |
| EP-0790986-A1 | ANILINE DERIVATIVES | ZENECA LIMITED (GB) | 1997-08-27 | — | — | EP | claimed |
| CN-1148810-A | Medicinal composition for treating glaucoma | SENJU PHARMA CO (JP) | 1997-04-30 | — | — | CN | claimed |
| EP-0759756-A1 | PHARMACEUTICAL COMPOSITION FOR TREATING GLAUCOMA CONTAINING TERAZOSIN | Senju Pharmaceutical Co., Ltd. (JP) | 1997-03-05 | — | — | EP | claimed |
| EP-0749426-A1 | QUINOLINE OR QUINAZOLINE DERIVATIVES AS ANTI-INFLAMMATORY AGENTS, IN PARTICULAR FOR TREATING ARTHRITIS | Takeda Chemical Industries, Ltd. (JP) | 1996-12-27 | — | — | EP | claimed |
| WO-1996015118-A1 | ANILINE DERIVATIVES | ZENECA LIMITED (GB) | 1996-05-23 | — | — | WO | claimed |
| WO-1995031200-A1 | PHARMACEUTICAL COMPOSITION FOR TREATING GLAUCOMA CONTAINING TERAZOSIN | SENJU PHARMACEUTICAL CO., LTD. (JP) | 1995-11-23 | — | — | WO | claimed |
| WO-1995024394-A1 | QUINOLINE OR QUINAZOLINE DERIVATIVES AS ANTI-INFLAMMATORY AGENTS, IN PARTICULAR FOR TREATING ARTHRITIS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1995-09-14 | — | — | WO | claimed |
| CN-1094043-A | Quinazoline derivant | ZENECA LTD (GB) | 1994-10-26 | — | — | CN | claimed |