SCHEMBL31723264

SCHEMBL31723264

Cc1c(N)cc(F)cc1Nc1cccc(F)c1

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
RAPGEF4 Q8WZA2 1/20 0.49
EGFR P00533 2/20 0.44
ABL1 P00519 1/20 0.44
ABL2 P42684 1/20 0.44
PTGS1 P23219 1/20 0.41
PTGS2 P35354 1/20 0.41
TAAR1 Q96RJ0 2/20 0.40
ABCG2 Q9UNQ0 2/20 0.40
P2RY4 P51582 2/20 0.40
RAB9A P51151 2/20 0.40
SMN1; SMN2 Q16637 2/20 0.40
TP53 P04637 2/20 0.40
MAPK1 P28482 1/20 0.40
HTT P42858 1/20 0.40
MKNK1 Q9BUB5 1/20 0.40
KDM4E B2RXH2 1/20 0.40
MEN1 O00255 1/20 0.40
NPC1 O15118 1/20 0.40
ALOX15 P16050 1/20 0.40
TSHR P16473 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29454098 1.00 RAPGEF4 (0.49) RAPGEF4EGFRABL1ABL2PTGS1
SCHEMBL22232047 1.00 RAPGEF4 (0.49) RAPGEF4EGFRABL1ABL2PTGS1
SCHEMBL22231966 0.89 NPSR1 (0.47) RAPGEF4EGFRABL1ABL2P2RY4
SCHEMBL31723222 0.89 NPSR1 (0.47) RAPGEF4EGFRABL1ABL2P2RY4
SCHEMBL29454120 0.89 NPSR1 (0.47) RAPGEF4EGFRABL1ABL2P2RY4
SCHEMBL22232539 0.87 MAPT (0.48) EGFRRAB9ASMN1; SMN2TP53MAPK1
SCHEMBL22232072 0.86 RAPGEF4 (0.45) RAPGEF4EGFRABL1ABL2PTGS1
SCHEMBL29454206 0.86 RAPGEF4 (0.45) RAPGEF4EGFRABL1ABL2PTGS1
SCHEMBL31723229 0.86 RAPGEF4 (0.45) RAPGEF4EGFRABL1ABL2PTGS1
SCHEMBL29454216 0.86 FADS1 (0.44) EGFRABL1ABL2RAB9ASMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4647426-A2 3-SUBSTITUTED PHENYLAMIDINE COMPOUNDS, PREPARATION AND USE THEREOF PI Industries Ltd. (IN) 2025-11-12 EP claimed