SCHEMBL31731147

SCHEMBL31731147

Cn1c(=O)n(C2CCC(=O)N(COCC[Si](C)(C)C)C2=O)c2ccc(C=O)cc21

nearest known ligand 0.35

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
▸ DDB1 Q16531 3/20 0.35
▸ CRBN Q96SW2 3/20 0.35
▸ KDM4E B2RXH2 1/20 0.31
▸ ALDH1A1 P00352 1/20 0.31
▸ CYP1A2 P05177 1/20 0.31
▸ CYP2C9 P11712 1/20 0.31
▸ HPGD P15428 1/20 0.31
▸ CYP2C19 P33261 1/20 0.31
▸ HSD17B10 Q99714 1/20 0.31
▸ DRD2 P14416 1/20 0.30
▸ SLC6A4 P31645 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31731259 0.87 DDB1 (0.36) DDB1CRBNDRD2SLC6A4
SCHEMBL31160705 0.87 DDB1 (0.36) DDB1CRBNDRD2SLC6A4
SCHEMBL31731245 0.87 DDB1 (0.36) DDB1CRBNDRD2SLC6A4
SCHEMBL31731564 0.84 DDB1 (0.34) DDB1CRBNALDH1A1CYP1A2
SCHEMBL30990746 0.84 DDB1 (0.32) DDB1CRBN
SCHEMBL31160670 0.83 DDB1 (0.34) DDB1CRBNDRD2SLC6A4
SCHEMBL30990711 0.82 DDB1 (0.35) DDB1CRBNDRD2SLC6A4
SCHEMBL30990692 0.82 DDB1 (0.35) DDB1CRBN
SCHEMBL31160701 0.82 DDB1 (0.35) DDB1CRBN
SCHEMBL31731318 0.81 DGAT1 (0.32) DDB1CRBN

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12606533-B2 3-phenylpropylamine derivative DAIICHI SANKYO COMPANY, LIMITED (JP) 2026-04-21 — — US disclosed
US-20250353824-A1 3-PHENYLPROPYLAMINE DERIVATIVE DAIICHI SANKYO COMPANY, LIMITED (JP) 2025-11-20 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250353824-A1 3-PHENYLPROPYLAMINE DERIVATIVE SF1, SF3A1, SFXN1 DDB1 1201/4885CRBN 2290/4885KDM4E 837/4885
US-12606533-B2 3-phenylpropylamine derivative SF3A1, SF1, HTR1D DDB1 363/4885CRBN 2904/4885KDM4E 260/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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