SCHEMBL31736748

SCHEMBL31736748

COC(=O)[C@H](Cc1cc(I)c(Oc2ccc(OCCl)c(I)c2)c(I)c1)NC(=O)C(F)(F)F

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PCNA P12004 7/20 0.41
THRB P10828 10/20 0.39
MEN1 O00255 7/20 0.39
KMT2A Q03164 7/20 0.39
LMNA P02545 6/20 0.39
THRA P10827 6/20 0.39
PPARG P37231 2/20 0.39
CYP2D6 P10635 1/20 0.39
TSHR P16473 1/20 0.39
GABRP O00591 1/20 0.39
GABRD O14764 1/20 0.39
ABCB11 O95342 1/20 0.39
F2 P00734 1/20 0.39
GABRA1 P14867 1/20 0.39
GABRB1 P18505 1/20 0.39
GABRG2 P18507 1/20 0.39
GABRB3 P28472 1/20 0.39
ADORA1 P30542 1/20 0.39
GABRA5 P31644 1/20 0.39
GABRA3 P34903 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31736607 0.89 PCNA (0.39) PCNATHRBMEN1KMT2ALMNA
SCHEMBL31737126 0.85 THRB (0.54) PCNATHRBMEN1KMT2ALMNA
SCHEMBL5114362 0.77 PCNA (0.48) PCNATSHR
SCHEMBL5114432 0.76 MDM4 (0.42) THRBMEN1KMT2ALMNAUSP2
SCHEMBL5549364 0.76 MDM4 (0.42) THRBMEN1KMT2ALMNAUSP2
SCHEMBL8731461 0.75 THRB (0.51) PCNATHRBMEN1KMT2ALMNA
SCHEMBL5114418 0.74 THRB (0.41) THRBMEN1KMT2ATHRAPOLB
SCHEMBL8047743 0.74 THRB (0.60) PCNATHRBMEN1KMT2ALMNA
SCHEMBL8047744 0.74 THRB (0.60) PCNATHRBMEN1KMT2ALMNA
SCHEMBL1980072 0.73 SMN1; SMN2 (0.36) MEN1KMT2ANPSR1ALDH1A1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2025245015-A1 THYROID HORMONE PRODRUGS AND COMPOSITIONS COMPRISING THE SAME REGENTS OF THE UNIVERSITY OF MINNESOTA (US) 2025-11-27 WO disclosed