SCHEMBL8047743

SCHEMBL8047743

O=C(O)C(Cc1cc(I)c(Oc2cc(I)c(O)c(I)c2)c(I)c1)NC(=O)C(F)(F)F

nearest known ligand 0.60

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
THRB P10828 11/20 0.60
THRA P10827 8/20 0.60
PPARG P37231 6/20 0.60
MEN1 O00255 5/20 0.60
KMT2A Q03164 5/20 0.60
LMNA P02545 4/20 0.60
TTR P02766 2/20 0.60
ADORA3 P0DMS8 2/20 0.60
PDE4D Q08499 2/20 0.60
HSD17B10 Q99714 2/20 0.60
RXRA P19793 2/20 0.60
NR1I2 O75469 2/20 0.60
NR3C1 P04150 1/20 0.60
CYP1A2 P05177 1/20 0.60
HTR1A P08908 1/20 0.60
CYP2C9 P11712 1/20 0.60
TBXA2R P21731 1/20 0.60
NTSR1 P30989 1/20 0.60
HTR2B P41595 1/20 0.60
USP2 O75604 1/20 0.60

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8047744 1.00 THRB (0.60) THRBTHRAPPARGMEN1KMT2A
SCHEMBL17612145 0.90 THRB (0.61) THRBTHRAPPARGMEN1KMT2A
SCHEMBL8731461 0.88 THRB (0.51) THRBTHRAPPARGMEN1KMT2A
SCHEMBL12844205 0.87 THRB (0.67) THRBTHRAPPARGMEN1KMT2A
SCHEMBL468892 0.86 THRB (0.69) THRBTHRAPPARGMEN1KMT2A
SCHEMBL28626300 0.86 THRB (0.65) THRBTHRAPPARGMEN1KMT2A
SCHEMBL468893 0.86 THRB (0.69) THRBTHRAPPARGMEN1KMT2A
SCHEMBL11190023 0.85 THRB (0.64) THRBTHRAPPARGMEN1KMT2A
SCHEMBL11190025 0.85 THRB (0.64) THRBTHRAPPARGMEN1KMT2A
SCHEMBL13949745 0.85 THRB (0.64) THRBTHRAPPARGMEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 26 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0303284-B2 Immunological method for the determination of free haptenic substances BRAHMS DIAGNOSTICA GMBH (DE) 2000-05-03 EP disclosed
US-H1018-H Immunological method for the determination of free substances having hapten properties HENNING BERLIN GMBH CHEMIE- UND PHARMAWERK (DE) 1992-01-07 US disclosed
EP-0303284-A1 Immunological method for the determination of free haptenic substances B.R.A.H.M.S Diagnostica GmbH (DE) 1989-02-15 EP disclosed
EP-0078477-B1 FENCLOFENAC AS TBP BLOCKING AGENT IN IODOTHYRONINE IMMUNOASSAYS MILES LABORATORIES, INC. (US) 1986-09-10 EP disclosed
US-4468469-A Substituted phenylacetic acids and salts as TBP blocking agents in iodothyronine immunoassays MILES LABORATORIES, INC. (US) 1984-08-28 US disclosed
EP-0078477-A2 Fenclofenac as TBP blocking agent in iodothyronine immunoassays MILES LABORATORIES, INC. (US) 1983-05-11 EP disclosed
US-4376165-A Method of preparing an enzyme-labeled ligand for use in specific binding assays and the labeled conjugate produced thereby MILES LABORATORIES, INC. (US) 1983-03-08 US disclosed
US-4363759-A PHOTOSENSITIVE MILES LABORATORIES, INC. (US) 1982-12-14 US disclosed
US-4355165-A CHEMILUMIMESCENCE, IMMUNOASSAY MILES LABORATORIES, INC. (US) 1982-10-19 US disclosed
US-4340668-A Heme-labeled specific binding assay MILES LABORATORIES, INC. (US) 1982-07-20 US disclosed
US-4297273-A MEDICAL DIAGNOSIS; IMMUNOASSAY MILES LABORATORIES, INC. (US) 1981-10-27 US disclosed
US-4261893-A INTERMEDIATES IN SYNTHESIS OF CHEMILUMINESCENT-LABELED CONJUGATES USED IN IMMUNOASSAYS MILES LABORATORIES, INC. (US) 1981-04-14 US disclosed
US-4238395-A INTERMEDIATE OF CHEMILUMINESCENT NAPHTHALENE-1,2-DICARBOXYLIC ACID HYDRAZIDE-LABELED CONJUGATES MILES LABORATORIES, INC. (US) 1980-12-09 US disclosed
US-4238565-A Specific binding assay with a prosthetic group as a label component MILES LABORATORIES, INC. (US) 1980-12-09 US disclosed
US-4226993-A INTERMEDIATES FOR CHEMILUMINESCENT LABELED CONJUGATES MILES LABORATORIES, INC. (US) 1980-10-07 US disclosed
US-4226992-A INTERMEDIATES FOR CHEMILUMINESCENT LABELED CONJUGATES MILES LABORATORIES, INC. (US) 1980-10-07 US disclosed
US-4225485-A Chemiluminescent naphthalene-1,2-dicarboxylic acid hydrazide-labeled polypeptides and proteins MILES LABORATORIES, INC. (US) 1980-09-30 US disclosed
US-4213893-A Flavin adenine dinucleotide-labeled conjugates for use in specific binding assays MILES LABORATORIES, INC. (US) 1980-07-22 US disclosed
US-4212805-A INTERMEDIATES OF PHTHALHYDRAZIDE-LABELED CONJUGATES MILES LABORATORIES, INC. (US) 1980-07-15 US disclosed
US-4171432-A LABELING HORMONES FOR THYROID TESTS MILES LABORATORIES, INC. (US) 1979-10-16 US disclosed